BRD-K16189898_CHIR-99021_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K16189898_CHIR-99021_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACADVL acyl-CoA dehydrogenase, very long chain
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA1 carbonic anhydrase I
CDA cytidine deaminase
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGB chromogranin B
CHI3L2 chitinase 3-like 2
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GSTA4 glutathione S-transferase alpha 4
H1F0 H1 histone family, member 0
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LTF lactotransferrin
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSX1 msh homeobox 1
NAMPT nicotinamide phosphoribosyltransferase
NEFL neurofilament, light polypeptide
PI3 peptidase inhibitor 3, skin-derived
PLAGL1 pleiomorphic adenoma gene-like 1
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
VSNL1 visinin-like 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAB39 calcium binding protein 39
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CSRP1 cysteine and glycine-rich protein 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMTF1 cyclin D binding myb-like transcription factor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FBP1 fructose-1,6-bisphosphatase 1
FNBP1L formin binding protein 1-like
GCH1 GTP cyclohydrolase 1
GCHFR GTP cyclohydrolase I feedback regulator
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMGN3 high mobility group nucleosomal binding domain 3
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
JCHAIN joining chain of multimeric IgA and IgM
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MTFR1 mitochondrial fission regulator 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PFDN4 prefoldin subunit 4
PLA2G16 phospholipase A2, group XVI
PTMA prothymosin, alpha
RPS27L ribosomal protein S27-like
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
STK39 serine threonine kinase 39
STS steroid sulfatase (microsomal), isozyme S
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TXNDC9 thioredoxin domain containing 9
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)