BRD-K16180117_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K16180117_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL8 chemokine (C-C motif) ligand 8
CHMP4A charged multivesicular body protein 4A
CLIC4 chloride intracellular channel 4
COL15A1 collagen, type XV, alpha 1
CRISP3 cysteine-rich secretory protein 3
CRYZ crystallin, zeta (quinone reductase)
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FXYD3 FXYD domain containing ion transport regulator 3
GBP1 guanylate binding protein 1, interferon-inducible
GREM1 gremlin 1, DAN family BMP antagonist
KIAA0101 KIAA0101
KLK6 kallikrein-related peptidase 6
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LYST lysosomal trafficking regulator
MAP7 microtubule-associated protein 7
MELK maternal embryonic leucine zipper kinase
NCK1 NCK adaptor protein 1
NPY neuropeptide Y
PDZRN3 PDZ domain containing ring finger 3
PLAGL1 pleiomorphic adenoma gene-like 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RALB v-ral simian leukemia viral oncogene homolog B
RDX radixin
RHCG Rh family, C glycoprotein
RPL10 ribosomal protein L10
RSRP1 arginine/serine-rich protein 1
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
UBE2A ubiquitin-conjugating enzyme E2A
VAMP7 vesicle-associated membrane protein 7
XPO7 exportin 7

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADORA2B adenosine A2b receptor
APOD apolipoprotein D
BCL6 B-cell CLL/lymphoma 6
CIRBP cold inducible RNA binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FBP1 fructose-1,6-bisphosphatase 1
FGFR4 fibroblast growth factor receptor 4
FHL1 four and a half LIM domains 1
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
LPL lipoprotein lipase
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MXRA7 matrix-remodelling associated 7
NES nestin
NNMT nicotinamide N-methyltransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIP prolactin-induced protein
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SLC38A1 solute carrier family 38, member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGOLN2 trans-golgi network protein 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN4 tetraspanin 4
TWF2 twinfilin actin binding protein 2
TXNDC9 thioredoxin domain containing 9
ZBTB16 zinc finger and BTB domain containing 16