BRD-K15916496_Clotrimazole_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K15916496_Clotrimazole_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CCL19 chemokine (C-C motif) ligand 19
DDIT4 DNA-damage-inducible transcript 4
FBP1 fructose-1,6-bisphosphatase 1
FHL1 four and a half LIM domains 1
GATA3 GATA binding protein 3
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
IL1B interleukin 1, beta
JCHAIN joining chain of multimeric IgA and IgM
LAMA3 laminin, alpha 3
LXN latexin
LY75 lymphocyte antigen 75
MAN1A1 mannosidase, alpha, class 1A, member 1
MXRA7 matrix-remodelling associated 7
NPR3 natriuretic peptide receptor 3
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLAT plasminogen activator, tissue
PLCB4 phospholipase C, beta 4
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
RGS5 regulator of G-protein signaling 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
THBS1 thrombospondin 1
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
DIO2 deiodinase, iodothyronine, type II
EIF5A eukaryotic translation initiation factor 5A
GPM6A glycoprotein M6A
HIST1H4C histone cluster 1, H4c
IL1R1 interleukin 1 receptor, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
NR2F1 nuclear receptor subfamily 2, group F, member 1
RGS2 regulator of G-protein signaling 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SPINK1 serine peptidase inhibitor, Kazal type 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
UBQLN2 ubiquilin 2