BRD-K15716662_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K15716662_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
CAPG capping protein (actin filament), gelsolin-like
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
CLIC4 chloride intracellular channel 4
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CYBRD1 cytochrome b reductase 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EDF1 endothelial differentiation-related factor 1
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FLNB filamin B, beta
FN1 fibronectin 1
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
IFRD1 interferon-related developmental regulator 1
IL6ST interleukin 6 signal transducer
IQGAP1 IQ motif containing GTPase activating protein 1
ITM2A integral membrane protein 2A
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MFSD10 major facilitator superfamily domain containing 10
MMP12 matrix metallopeptidase 12
MSRB2 methionine sulfoxide reductase B2
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NQO2 NAD(P)H dehydrogenase, quinone 2
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFD platelet derived growth factor D
PHGDH phosphoglycerate dehydrogenase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAP1GAP RAP1 GTPase activating protein
RRAGD Ras-related GTP binding D
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SAV1 salvador family WW domain containing protein 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SRPX sushi-repeat containing protein, X-linked
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TPM4 tropomyosin 4
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGAP29 Rho GTPase activating protein 29
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COMMD8 COMM domain containing 8
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EVL Enah/Vasp-like
GAGE3 G antigen 3
GNAS GNAS complex locus
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IPO13 importin 13
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0101 KIAA0101
KIAA1467 KIAA1467
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MKI67 marker of proliferation Ki-67
NCAPH non-SMC condensin I complex, subunit H
NPTN neuroplastin
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAD23B RAD23 homolog B (S. cerevisiae)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SNX10 sorting nexin 10
THAP11 THAP domain containing 11
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSC22D1 TSC22 domain family, member 1
TUSC3 tumor suppressor candidate 3