BRD-K15716662_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K15716662_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CLDN4 claudin 4
COL11A1 collagen, type XI, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFT57 intraflagellar transport 57
IL6 interleukin 6
INHBA inhibin, beta A
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM4 olfactomedin 4
PITX1 paired-like homeodomain 1
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PYCARD PYD and CARD domain containing
REEP5 receptor accessory protein 5
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX9 SRY (sex determining region Y)-box 9
SULF1 sulfatase 1
TLR4 toll-like receptor 4
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TUFT1 tuftelin 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ATMIN ATM interactor
C2CD2 C2 calcium-dependent domain containing 2
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
COL7A1 collagen, type VII, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CRIP1 cysteine-rich protein 1 (intestinal)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
DND1 DND microRNA-mediated repression inhibitor 1
FAM13A family with sequence similarity 13, member A
FASTKD5 FAST kinase domains 5
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KIAA0907 KIAA0907
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LINC00341 long intergenic non-protein coding RNA 341
LONP2 lon peptidase 2, peroxisomal
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAT2A methionine adenosyltransferase II, alpha
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFM1 olfactomedin 1
RORA RAR-related orphan receptor A
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RSRP1 arginine/serine-rich protein 1
RUNX3 runt-related transcription factor 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TARDBP TAR DNA binding protein
TCP1 t-complex 1
TDO2 tryptophan 2,3-dioxygenase
TRAK2 trafficking protein, kinesin binding 2
TTC3 tetratricopeptide repeat domain 3
ZC3HAV1 zinc finger CCCH-type, antiviral 1