BRD-K15616905_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K15616905_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
ADGRG1 adhesion G protein-coupled receptor G1
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CAB39 calcium binding protein 39
CARS cysteinyl-tRNA synthetase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
COG5 component of oligomeric golgi complex 5
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GRB10 growth factor receptor-bound protein 10
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
IARS isoleucyl-tRNA synthetase
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
IRF1 interferon regulatory factor 1
ITM2A integral membrane protein 2A
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF9 Kruppel-like factor 9
KRCC1 lysine-rich coiled-coil 1
KRT23 keratin 23, type I
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RND3 Rho family GTPase 3
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFRP1 secreted frizzled-related protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
SRPK2 SRSF protein kinase 2
STC2 stanniocalcin 2
TBC1D31 TBC1 domain family, member 31
TES testin LIM domain protein
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
WARS tryptophanyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ATF5 activating transcription factor 5
C14ORF132 chromosome 14 open reading frame 132
CDC25A cell division cycle 25A
CP ceruloplasmin (ferroxidase)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
ENDOD1 endonuclease domain containing 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
GATA2 GATA binding protein 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXB2 homeobox B2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
JCHAIN joining chain of multimeric IgA and IgM
KRT6A keratin 6A, type II
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFSD10 major facilitator superfamily domain containing 10
MRPS2 mitochondrial ribosomal protein S2
MSX1 msh homeobox 1
ORC1 origin recognition complex, subunit 1
PAEP progestagen-associated endometrial protein
PDZD2 PDZ domain containing 2
PMPCA peptidase (mitochondrial processing) alpha
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC2 syndecan 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPON1 spondin 1, extracellular matrix protein
STS steroid sulfatase (microsomal), isozyme S
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
ZNF512B zinc finger protein 512B