BRD-K15600710_S1057_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K15600710_S1057_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
AREG amphiregulin
ASS1 argininosuccinate synthase 1
BIK BCL2-interacting killer (apoptosis-inducing)
C14ORF132 chromosome 14 open reading frame 132
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
CST3 cystatin C
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
EGFL6 EGF-like-domain, multiple 6
EPAS1 endothelial PAS domain protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FRY furry homolog (Drosophila)
GAS6 growth arrest-specific 6
GSN gelsolin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HLA-E major histocompatibility complex, class I, E
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGL immunoglobulin lambda locus
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
MSLN mesothelin
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PDE4DIP phosphodiesterase 4D interacting protein
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRSS2 protease, serine, 2 (trypsin 2)
PRUNE2 prune homolog 2 (Drosophila)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VNN1 vanin 1

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP2M1 adaptor-related protein complex 2, mu 1 subunit
BAG2 BCL2-associated athanogene 2
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDCA8 cell division cycle associated 8
CLU clusterin
COPS7A COP9 signalosome subunit 7A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBNA1BP2 EBNA1 binding protein 2
ECT2 epithelial cell transforming 2
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXO3 F-box protein 3
FEN1 flap structure-specific endonuclease 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTF2A2 general transcription factor IIA, 2, 12kDa
HAT1 histone acetyltransferase 1
HES1 hes family bHLH transcription factor 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
LBH limb bud and heart development
LIG1 ligase I, DNA, ATP-dependent
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MYCBP MYC binding protein
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PALLD palladin, cytoskeletal associated protein
PCNA proliferating cell nuclear antigen
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPF4 pre-mRNA processing factor 4
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
RFC4 replication factor C (activator 1) 4, 37kDa
RND3 Rho family GTPase 3
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SEPW1 selenoprotein W, 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPG small nuclear ribonucleoprotein polypeptide G
STMN1 stathmin 1
TMEM176B transmembrane protein 176B
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSPAN12 tetraspanin 12
TXNDC9 thioredoxin domain containing 9
WDR61 WD repeat domain 61
WWTR1 WW domain containing transcription regulator 1
ZNF586 zinc finger protein 586