BRD-K15563106_-666_SW620_6.0_h_177.6_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K15563106_-666_SW620_6.0_h_177.6_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CAPG capping protein (actin filament), gelsolin-like
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL9A3 collagen, type IX, alpha 3
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
ECHDC2 enoyl CoA hydratase domain containing 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GMDS GDP-mannose 4,6-dehydratase
GPRASP1 G protein-coupled receptor associated sorting protein 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL7R interleukin 7 receptor
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1F metallothionein 1F
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGDS prostaglandin D2 synthase 21kDa (brain)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A10 S100 calcium binding protein A10
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SRGN serglycin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
VCAM1 vascular cell adhesion molecule 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
APMAP adipocyte plasma membrane associated protein
ASPH aspartate beta-hydroxylase
ASRGL1 asparaginase like 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CKAP4 cytoskeleton-associated protein 4
DUSP6 dual specificity phosphatase 6
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FHL1 four and a half LIM domains 1
GPX1 glutathione peroxidase 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IGFBP5 insulin-like growth factor binding protein 5
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
NUP50 nucleoporin 50kDa
PEG10 paternally expressed 10
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM70 transmembrane protein 70
USP22 ubiquitin specific peptidase 22
VCAN versican