BRD-K15563106_-666_MCF7_6.0_h_177.6_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K15563106_-666_MCF7_6.0_h_177.6_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
APOLD1 apolipoprotein L domain containing 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CCL20 chemokine (C-C motif) ligand 20
CD1E CD1e molecule
CD36 CD36 molecule (thrombospondin receptor)
CDK16 cyclin-dependent kinase 16
CDKN2A cyclin-dependent kinase inhibitor 2A
CES1 carboxylesterase 1
CHN2 chimerin 2
CLDN3 claudin 3
CNPY3 canopy FGF signaling regulator 3
COL11A1 collagen, type XI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CTGF connective tissue growth factor
CTTN cortactin
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS7 growth arrest-specific 7
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LPL lipoprotein lipase
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCTP1 multiple C2 domains, transmembrane 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPY1R neuropeptide Y receptor Y1
PKP2 plakophilin 2
PNKP polynucleotide kinase 3'-phosphatase
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRAME preferentially expressed antigen in melanoma
PSPH phosphoserine phosphatase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SST somatostatin
SYT1 synaptotagmin I
TAGLN transgelin
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM259 transmembrane protein 259
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
TUSC3 tumor suppressor candidate 3
TYMP thymidine phosphorylase
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASXL2 additional sex combs like transcriptional regulator 2
ATF5 activating transcription factor 5
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FEN1 flap structure-specific endonuclease 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IFI44L interferon-induced protein 44-like
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANK2 KN motif and ankyrin repeat domains 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
LONP2 lon peptidase 2, peroxisomal
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK6 mitogen-activated protein kinase 6
MCM10 minichromosome maintenance complex component 10
MED1 mediator complex subunit 1
METTL13 methyltransferase like 13
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP56 NOP56 ribonucleoprotein
NQO1 NAD(P)H dehydrogenase, quinone 1
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G15 phospholipase A2, group XV
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RABIF RAB interacting factor
RALGDS ral guanine nucleotide dissociation stimulator
RPP38 ribonuclease P/MRP 38kDa subunit
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TSC22D2 TSC22 domain family, member 2
WIPF2 WAS/WASL interacting protein family, member 2
ZC3H4 zinc finger CCCH-type containing 4
ZMIZ1 zinc finger, MIZ-type containing 1