BRD-K15563106_-666_MCF7_24.0_h_177.6_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K15563106_-666_MCF7_24.0_h_177.6_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
CREB3L2 cAMP responsive element binding protein 3-like 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FRY furry homolog (Drosophila)
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GRB10 growth factor receptor-bound protein 10
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IL32 interleukin 32
JUN jun proto-oncogene
KAZN kazrin, periplakin interacting protein
KLF4 Kruppel-like factor 4 (gut)
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
MARS methionyl-tRNA synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA4 protein disulfide isomerase family A, member 4
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAF2 PRA1 domain family, member 2
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TES testin LIM domain protein
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC5 baculoviral IAP repeat containing 5
C7 complement component 7
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFNB2 ephrin-B2
EPHA4 EPH receptor A4
FASN fatty acid synthase
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPER1 G protein-coupled estrogen receptor 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KANK2 KN motif and ankyrin repeat domains 2
MATN2 matrilin 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
OXTR oxytocin receptor
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RRM2 ribonucleotide reductase M2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
STMN1 stathmin 1
TCF4 transcription factor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
ZWINT ZW10 interacting kinetochore protein