BRD-K15563106_-666_HEPG2_6.0_h_177.6_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K15563106_-666_HEPG2_6.0_h_177.6_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CCND2 cyclin D2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
DCHS1 dachsous cadherin-related 1
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPHB2 EPH receptor B2
ESRP1 epithelial splicing regulatory protein 1
FAM129A family with sequence similarity 129, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
G0S2 G0/G1 switch 2
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGFBP5 insulin-like growth factor binding protein 5
INSM1 insulinoma-associated 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0226L KIAA0226-like
LPAR2 lysophosphatidic acid receptor 2
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PDLIM3 PDZ and LIM domain 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPARG peroxisome proliferator-activated receptor gamma
PRDX2 peroxiredoxin 2
PRKCI protein kinase C, iota
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCAN2 regulator of calcineurin 2
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPRY4 sprouty homolog 4 (Drosophila)
SSPN sarcospan
ST18 suppression of tumorigenicity 18, zinc finger
STK39 serine threonine kinase 39
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ATF5 activating transcription factor 5
BLCAP bladder cancer associated protein
BMP4 bone morphogenetic protein 4
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
FAM57A family with sequence similarity 57, member A
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXC6 homeobox C6
KIF2C kinesin family member 2C
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LIPT1 lipoyltransferase 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGED1 melanoma antigen family D1
MAT2A methionine adenosyltransferase II, alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMD4A sterile alpha motif domain containing 4A
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMEM2 transmembrane protein 2
TRAK2 trafficking protein, kinesin binding 2
VGLL4 vestigial-like family member 4
WIF1 WNT inhibitory factor 1