BRD-K15409150_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K15409150_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GUSBP11 glucuronidase, beta pseudogene 11
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NKX2-1 NK2 homeobox 1
NOTCH2NL notch 2 N-terminal like
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PAEP progestagen-associated endometrial protein
PDE4C phosphodiesterase 4C, cAMP-specific
PLXNC1 plexin C1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
RABGAP1L RAB GTPase activating protein 1-like
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35E1 solute carrier family 35, member E1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TOB1 transducer of ERBB2, 1
UFM1 ubiquitin-fold modifier 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF160 zinc finger protein 160

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CALD1 caldesmon 1
CAV2 caveolin 2
CD44 CD44 molecule (Indian blood group)
CDC42 cell division cycle 42
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COPS7A COP9 signalosome subunit 7A
CP ceruloplasmin (ferroxidase)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
GCLC glutamate-cysteine ligase, catalytic subunit
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
KCTD12 potassium channel tetramerization domain containing 12
MCUR1 mitochondrial calcium uniporter regulator 1
MXRA7 matrix-remodelling associated 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NTS neurotensin
PI3 peptidase inhibitor 3, skin-derived
PLBD1 phospholipase B domain containing 1
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
RAB13 RAB13, member RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STK39 serine threonine kinase 39
TGFBI transforming growth factor, beta-induced, 68kDa
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
WNT5A wingless-type MMTV integration site family, member 5A