BRD-K15166186_TL_HRAS27 BRD-K15166186_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K15166186_TL_HRAS27 BRD-K15166186_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP1 dual specificity phosphatase 1
FADS1 fatty acid desaturase 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GABARAPL1 GABA(A) receptor-associated protein like 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MSMO1 methylsterol monooxygenase 1
NLGN4X neuroligin 4, X-linked
NR4A1 nuclear receptor subfamily 4, group A, member 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ARMCX2 armadillo repeat containing, X-linked 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
GSTM3 glutathione S-transferase mu 3 (brain)
IFI6 interferon, alpha-inducible protein 6
MYL9 myosin, light chain 9, regulatory
S100A6 S100 calcium binding protein A6
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
THY1 Thy-1 cell surface antigen