BRD-K15108141_gemcitabine_NCIH2073_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K15108141_gemcitabine_NCIH2073_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
C3 complement component 3
CASP2 caspase 2, apoptosis-related cysteine peptidase
CLU clusterin
CNPY3 canopy FGF signaling regulator 3
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSTA cystatin A (stefin A)
CXCR4 chemokine (C-X-C motif) receptor 4
DEGS1 delta(4)-desaturase, sphingolipid 1
EML3 echinoderm microtubule associated protein like 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GOLGA8B golgin A8 family, member B
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOOK2 hook microtubule-tethering protein 2
ITGA7 integrin, alpha 7
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS8 lectin, galactoside-binding, soluble, 8
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100505650 uncharacterized LOC100505650
LTBP3 latent transforming growth factor beta binding protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MBOAT7 membrane bound O-acyltransferase domain containing 7
MTA1 metastasis associated 1
NFIL3 nuclear factor, interleukin 3 regulated
NOV nephroblastoma overexpressed
PKM pyruvate kinase, muscle
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF6 serine/arginine-rich splicing factor 6
STX3 syntaxin 3
TRIM2 tripartite motif containing 2
TXNL4B thioredoxin-like 4B
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ANXA3 annexin A3
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
AURKA aurora kinase A
CAST calpastatin
CD24 CD24 molecule
CDC20 cell division cycle 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
CRABP1 cellular retinoic acid binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSTN destrin (actin depolymerizing factor)
EIF4E2 eukaryotic translation initiation factor 4E family member 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBD hemoglobin, delta
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
NFIB nuclear factor I/B
PCDH9 protocadherin 9
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PTX3 pentraxin 3, long
PXMP2 peroxisomal membrane protein 2, 22kDa
RPS27L ribosomal protein S27-like
STOM stomatin
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TUBB2B tubulin, beta 2B class IIb
UBE2C ubiquitin-conjugating enzyme E2C
UPP1 uridine phosphorylase 1
VCAN versican
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZNF185 zinc finger protein 185 (LIM domain)