BRD-K15025317_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K15025317_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
CADM1 cell adhesion molecule 1
CAST calpastatin
CD52 CD52 molecule
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPE carboxypeptidase E
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
EFHD1 EF-hand domain family, member D1
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
GAGE3 G antigen 3
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGHM immunoglobulin heavy constant mu
ISYNA1 inositol-3-phosphate synthase 1
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LDB3 LIM domain binding 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LRMP lymphoid-restricted membrane protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPZL2 myelin protein zero-like 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PDLIM3 PDZ and LIM domain 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAI14 retinoic acid induced 14
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
SCGB1D2 secretoglobin, family 1D, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMEM30B transmembrane protein 30B
TRDV3 T cell receptor delta variable 3
TSPAN7 tetraspanin 7
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTB actin, beta
AFF1 AF4/FMR2 family, member 1
AIM2 absent in melanoma 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPF centromere protein F, 350/400kDa
CHSY1 chondroitin sulfate synthase 1
CLTC clathrin, heavy chain (Hc)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDNRB endothelin receptor type B
EPRS glutamyl-prolyl-tRNA synthetase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GOLM1 golgi membrane protein 1
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMG20B high mobility group 20B
HN1 hematological and neurological expressed 1
IL6ST interleukin 6 signal transducer
ITGA6 integrin, alpha 6
JADE1 jade family PHD finger 1
KAT6A K(lysine) acetyltransferase 6A
KIF14 kinesin family member 14
KRT10 keratin 10, type I
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LASP1 LIM and SH3 protein 1
MAPK6 mitogen-activated protein kinase 6
MED1 mediator complex subunit 1
PHB prohibitin
PI3 peptidase inhibitor 3, skin-derived
PLP1 proteolipid protein 1
PRDX2 peroxiredoxin 2
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTCH1 patched 1
SACS sacsin molecular chaperone
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
TBC1D4 TBC1 domain family, member 4
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TLE3 transducin-like enhancer of split 3
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2B topoisomerase (DNA) II beta 180kDa
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
ZCCHC24 zinc finger, CCHC domain containing 24