BRD-K14939371_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-K14939371_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AREG amphiregulin
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CTSZ cathepsin Z
CX3CR1 chemokine (C-X3-C motif) receptor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EHF ets homologous factor
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM198B family with sequence similarity 198, member B
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
IGKC immunoglobulin kappa constant
ITGA6 integrin, alpha 6
LAMP3 lysosomal-associated membrane protein 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PAWR PRKC, apoptosis, WT1, regulator
PECAM1 platelet/endothelial cell adhesion molecule 1
PLN phospholamban
PODXL podocalyxin-like
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCQ protein kinase C, theta
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
TAGLN transgelin
TCL1A T-cell leukemia/lymphoma 1A
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TRD T cell receptor delta locus
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UBE3B ubiquitin protein ligase E3B
WDR7 WD repeat domain 7
ZNF91 zinc finger protein 91
ZYX zyxin

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ARMCX6 armadillo repeat containing, X-linked 6
ATF1 activating transcription factor 1
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CISH cytokine inducible SH2-containing protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSE cathepsin E
DCK deoxycytidine kinase
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGFL6 EGF-like-domain, multiple 6
ESR1 estrogen receptor 1
FEN1 flap structure-specific endonuclease 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO3 flavin containing monooxygenase 3
FOLR1 folate receptor 1 (adult)
GGT1 gamma-glutamyltransferase 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSPT2 G1 to S phase transition 2
H1F0 H1 histone family, member 0
IGSF3 immunoglobulin superfamily, member 3
IQCG IQ motif containing G
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MSLN mesothelin
MUC1 mucin 1, cell surface associated
NCK1 NCK adaptor protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
PAM peptidylglycine alpha-amidating monooxygenase
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PSPH phosphoserine phosphatase
RAD51AP1 RAD51 associated protein 1
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SYNGR2 synaptogyrin 2
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRIP6 thyroid hormone receptor interactor 6
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XBP1 X-box binding protein 1