BRD-K14821540_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K14821540_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADD3 adducin 3 (gamma)
AHR aryl hydrocarbon receptor
ALCAM activated leukocyte cell adhesion molecule
ANO1 anoctamin 1, calcium activated chloride channel
ANXA10 annexin A10
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAD BCL2-associated agonist of cell death
BTG1 B-cell translocation gene 1, anti-proliferative
BUD31 BUD31 homolog (S. cerevisiae)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARS cysteinyl-tRNA synthetase
CCNB2 cyclin B2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF1 eukaryotic translation initiation factor 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EPRS glutamyl-prolyl-tRNA synthetase
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GHITM growth hormone inducible transmembrane protein
GOT1 glutamic-oxaloacetic transaminase 1, soluble
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL1A interleukin 1, alpha
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JOSD1 Josephin domain containing 1
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MOCOS molybdenum cofactor sulfurase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIL3 nuclear factor, interleukin 3 regulated
NOV nephroblastoma overexpressed
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAB6A RAB6A, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RBM47 RNA binding motif protein 47
RIOK3 RIO kinase 3
RSL24D1 ribosomal L24 domain containing 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCRG1 stimulator of chondrogenesis 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
STC2 stanniocalcin 2
STRAP serine/threonine kinase receptor associated protein
TARS threonyl-tRNA synthetase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP1 tight junction protein 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
B3GNT1
C1QTNF3 C1q and tumor necrosis factor related protein 3
CCNF cyclin F
CD200 CD200 molecule
CDC25A cell division cycle 25A
COL5A1 collagen, type V, alpha 1
CTSZ cathepsin Z
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYTL1 cytokine-like 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPB8 heat shock 22kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KCTD12 potassium channel tetramerization domain containing 12
LDOC1 leucine zipper, down-regulated in cancer 1
LIG1 ligase I, DNA, ATP-dependent
LOC100505650 uncharacterized LOC100505650
MCM5 minichromosome maintenance complex component 5
MLEC malectin
MSH6 mutS homolog 6
NME4 NME/NM23 nucleoside diphosphate kinase 4
OBSL1 obscurin-like 1
PBX3 pre-B-cell leukemia homeobox 3
PCCB propionyl CoA carboxylase, beta polypeptide
PI3 peptidase inhibitor 3, skin-derived
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PPL periplakin
PRKCB protein kinase C, beta
RGS2 regulator of G-protein signaling 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A9 S100 calcium binding protein A9
SALL2 spalt-like transcription factor 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC46A3 solute carrier family 46, member 3
SOX4 SRY (sex determining region Y)-box 4
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97