BRD-K14788918_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K14788918_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COL9A3 collagen, type IX, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRLF1 cytokine receptor-like factor 1
CSNK1E casein kinase 1, epsilon
CYB5R2 cytochrome b5 reductase 2
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP3 dual specificity phosphatase 3
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IGFBP3 insulin-like growth factor binding protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
KDM3A lysine (K)-specific demethylase 3A
KRT17 keratin 17, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LITAF lipopolysaccharide-induced TNF factor
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MBP myelin basic protein
MMP12 matrix metallopeptidase 12
MSLN mesothelin
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NNMT nicotinamide N-methyltransferase
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK6 proprotein convertase subtilisin/kexin type 6
PERP PERP, TP53 apoptosis effector
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMP22 peripheral myelin protein 22
PPAP2C phosphatidic acid phosphatase type 2C
PRKCZ protein kinase C, zeta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFRC transferrin receptor
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TUBA4A tubulin, alpha 4a
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ARMCX1 armadillo repeat containing, X-linked 1
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CD8A CD8a molecule
CDC20 cell division cycle 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CNN3 calponin 3, acidic
CXCL12 chemokine (C-X-C motif) ligand 12
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EPS8 epidermal growth factor receptor pathway substrate 8
FBXL12 F-box and leucine-rich repeat protein 12
G0S2 G0/G1 switch 2
GAS1 growth arrest-specific 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2AC histone cluster 1, H2ac
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
LAMB1 laminin, beta 1
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
NID1 nidogen 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PALMD palmdelphin
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRRX1 paired related homeobox 1
PTX3 pentraxin 3, long
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB3 Rho-related BTB domain containing 3
SYT1 synaptotagmin I
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
XIST X inactive specific transcript (non-protein coding)