BRD-K14618467_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K14618467_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALB albumin
ANKRD10 ankyrin repeat domain 10
APOA1 apolipoprotein A-I
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AXIN1 axin 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BSG basigin (Ok blood group)
CCND1 cyclin D1
CFB complement factor B
CORO1C coronin, actin binding protein, 1C
CREM cAMP responsive element modulator
CRIP2 cysteine-rich protein 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPCAM epithelial cell adhesion molecule
EREG epiregulin
FASN fatty acid synthase
FLNA filamin A, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GEM GTP binding protein overexpressed in skeletal muscle
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER2 immediate early response 2
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
LAMP1 lysosomal-associated membrane protein 1
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MED13L mediator complex subunit 13-like
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NPY1R neuropeptide Y receptor Y1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAT ornithine aminotransferase
OSBPL10 oxysterol binding protein-like 10
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PSAP prosaposin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SIK1 salt-inducible kinase 1
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQLE squalene epoxidase
SST somatostatin
STC1 stanniocalcin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPRSS3 transmembrane protease, serine 3
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
TUSC3 tumor suppressor candidate 3
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP4 aquaporin 4
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AUTS2 autism susceptibility candidate 2
BLCAP bladder cancer associated protein
BRCA1 breast cancer 1, early onset
CDC20 cell division cycle 20
CENPE centromere protein E, 312kDa
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EED embryonic ectoderm development
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GATA2 GATA binding protein 2
GCLM glutamate-cysteine ligase, modifier subunit
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IGHD immunoglobulin heavy constant delta
IGLJ3 immunoglobulin lambda joining 3
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KRT15 keratin 15, type I
MAN1C1 mannosidase, alpha, class 1C, member 1
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
METTL3 methyltransferase like 3
NCAPG non-SMC condensin I complex, subunit G
NRIP1 nuclear receptor interacting protein 1
PDCD2 programmed cell death 2
PEA15 phosphoprotein enriched in astrocytes 15
PEX11A peroxisomal biogenesis factor 11 alpha
PMM2 phosphomannomutase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
TBP TATA box binding protein
TCF4 transcription factor 4
TLR4 toll-like receptor 4
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
ZNF302 zinc finger protein 302