BRD-K14618467_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K14618467_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
APOA1 apolipoprotein A-I
ARF1 ADP-ribosylation factor 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCNG2 cyclin G2
CD24 CD24 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETN2 centrin, EF-hand protein, 2
CLGN calmegin
CREB3L2 cAMP responsive element binding protein 3-like 2
CRIP2 cysteine-rich protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAZAP2 DAZ associated protein 2
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN5 high mobility group nucleosome binding domain 5
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LDLR low density lipoprotein receptor
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MICB MHC class I polypeptide-related sequence B
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFRL platelet-derived growth factor receptor-like
PER1 period circadian clock 1
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
RAD9A RAD9 homolog A (S. pombe)
RPS27L ribosomal protein S27-like
RRAGD Ras-related GTP binding D
SARAF store-operated calcium entry-associated regulatory factor
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEC61B Sec61 beta subunit
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SREBF2 sterol regulatory element binding transcription factor 2
SSR4 signal sequence receptor, delta
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTBD3 BTB (POZ) domain containing 3
CA2 carbonic anhydrase II
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKLF chemokine-like factor
CSK c-src tyrosine kinase
CTSZ cathepsin Z
CX3CR1 chemokine (C-X3-C motif) receptor 1
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EED embryonic ectoderm development
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GATA2 GATA binding protein 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HOMER1 homer scaffolding protein 1
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT17 keratin 17, type I
MAT2A methionine adenosyltransferase II, alpha
MET MET proto-oncogene, receptor tyrosine kinase
MSH6 mutS homolog 6
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NOP16 NOP16 nucleolar protein
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PDCD2 programmed cell death 2
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PLK2 polo-like kinase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TRAPPC4 trafficking protein particle complex 4
TSPAN8 tetraspanin 8
WDR3 WD repeat domain 3