BRD-K14618467_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-K14618467_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ANXA1 annexin A1
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNL1 cyclin L1
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLCA4 chloride channel accessory 4
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CRABP1 cellular retinoic acid binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EREG epiregulin
FAM171A1 family with sequence similarity 171, member A1
FASTKD5 FAST kinase domains 5
FBXL12 F-box and leucine-rich repeat protein 12
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HOXA5 homeobox A5
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1R1 interleukin 1 receptor, type I
IRS2 insulin receptor substrate 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MEIS2 Meis homeobox 2
MIR22HG MIR22 host gene
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1E metallothionein 1E
MT1M metallothionein 1M
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXF1 nuclear RNA export factor 1
OSER1 oxidative stress responsive serine-rich 1
PEG3 paternally expressed 3
PER2 period circadian clock 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RBM15 RNA binding motif protein 15
RND3 Rho family GTPase 3
RNF139 ring finger protein 139
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SST somatostatin
STK17B serine/threonine kinase 17b
TBX2 T-box 2
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM255A transmembrane protein 255A
TOP1 topoisomerase (DNA) I
TRIB1 tribbles pseudokinase 1
TRIM36 tripartite motif containing 36
TSC22D2 TSC22 domain family, member 2
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10
ZFP36 ZFP36 ring finger protein
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABLIM1 actin binding LIM protein 1
ADAM10 ADAM metallopeptidase domain 10
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
ANXA7 annexin A7
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASPH aspartate beta-hydroxylase
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CALR calreticulin
CANX calnexin
CAPRIN1 cell cycle associated protein 1
CD36 CD36 molecule (thrombospondin receptor)
CLCN3 chloride channel, voltage-sensitive 3
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPNE3 copine III
CTSB cathepsin B
CTSH cathepsin H
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL2 dihydropyrimidinase-like 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPRS glutamyl-prolyl-tRNA synthetase
ERBB3 erb-b2 receptor tyrosine kinase 3
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GLB1 galactosidase, beta 1
HAUS4 HAUS augmin-like complex, subunit 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFITM2 interferon induced transmembrane protein 2
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL32 interleukin 32
LBR lamin B receptor
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LTF lactotransferrin
LYPLA1 lysophospholipase I
MACF1 microtubule-actin crosslinking factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTCH2 mitochondrial carrier 2
NAP1L1 nucleosome assembly protein 1-like 1
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NREP neuronal regeneration related protein
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PCM1 pericentriolar material 1
PDIA4 protein disulfide isomerase family A, member 4
PGK1 phosphoglycerate kinase 1
PIP prolactin-induced protein
PKM pyruvate kinase, muscle
PLA2G16 phospholipase A2, group XVI
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PROM1 prominin 1
PROS1 protein S (alpha)
PSPH phosphoserine phosphatase
PXDN peroxidasin
QKI QKI, KH domain containing, RNA binding
RBBP4 retinoblastoma binding protein 4
RBPMS RNA binding protein with multiple splicing
RHOBTB3 Rho-related BTB domain containing 3
RPA1 replication protein A1, 70kDa
SET SET nuclear proto-oncogene
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTBN1 spectrin, beta, non-erythrocytic 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBP TATA box binding protein
TFRC transferrin receptor
TMEM2 transmembrane protein 2
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TTC3 tetratricopeptide repeat domain 3
TUBB tubulin, beta class I
TYMS thymidylate synthetase
USO1 USO1 vesicle transport factor
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VCAN versican
WFDC2 WAP four-disulfide core domain 2