BRD-K14200658_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K14200658_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
FADS1 fatty acid desaturase 1
FAM63A family with sequence similarity 63, member A
GREM1 gremlin 1, DAN family BMP antagonist
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ILK integrin-linked kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
MAB21L2 mab-21-like 2 (C. elegans)
MAN1A1 mannosidase, alpha, class 1A, member 1
NEBL nebulette
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNKP polynucleotide kinase 3'-phosphatase
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SMOX spermine oxidase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIL TLR4 interactor with leucine-rich repeats
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ATF5 activating transcription factor 5
CTPS1 CTP synthase 1
DERL1 derlin 1
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
LYZ lysozyme
MECOM MDS1 and EVI1 complex locus
MMP12 matrix metallopeptidase 12
NEFH neurofilament, heavy polypeptide
NR2F2 nuclear receptor subfamily 2, group F, member 2
P3H2 prolyl 3-hydroxylase 2
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
RAD51C RAD51 paralog C
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
SRGN serglycin
TBC1D31 TBC1 domain family, member 31
TBX2 T-box 2
TGFBR3 transforming growth factor, beta receptor III
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOR1A torsin family 1, member A (torsin A)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TWIST1 twist family bHLH transcription factor 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WT1 Wilms tumor 1