BRD-K14109347_LY2603618_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K14109347_LY2603618_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADA adenosine deaminase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FDXR ferredoxin reductase
FOSL1 FOS-like antigen 1
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
IER5 immediate early response 5
IRS1 insulin receptor substrate 1
KDM5D lysine (K)-specific demethylase 5D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP1 matrix metallopeptidase 1
NPY1R neuropeptide Y receptor Y1
PRKCB protein kinase C, beta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
TMEM47 transmembrane protein 47
TSPAN8 tetraspanin 8
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATAD2 ATPase family, AAA domain containing 2
ATG3 autophagy related 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A2 collagen, type V, alpha 2
CSTA cystatin A (stefin A)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FBXO5 F-box protein 5
FGFR3 fibroblast growth factor receptor 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KIF23 kinesin family member 23
KRT15 keratin 15, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LPAR6 lysophosphatidic acid receptor 6
MYBPC1 myosin binding protein C, slow type
NCK1 NCK adaptor protein 1
PBK PDZ binding kinase
PDZK1IP1 PDZK1 interacting protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PSIP1 PC4 and SFRS1 interacting protein 1
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TMPO thymopoietin
TNS3 tensin 3
VCAN versican
XIST X inactive specific transcript (non-protein coding)