BRD-K14027855_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K14027855_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD3 abhydrolase domain containing 3
ACTC1 actin, alpha, cardiac muscle 1
ADAM19 ADAM metallopeptidase domain 19
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLEC2B C-type lectin domain family 2, member B
CLIP3 CAP-GLY domain containing linker protein 3
CNPY3 canopy FGF signaling regulator 3
COL1A2 collagen, type I, alpha 2
CTGF connective tissue growth factor
CTSL cathepsin L
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EFS embryonal Fyn-associated substrate
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXD1 forkhead box D1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GPI glucose-6-phosphate isomerase
GRB10 growth factor receptor-bound protein 10
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NMU neuromedin U
NPC1 Niemann-Pick disease, type C1
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIT1 Ras-like without CAAX 1
RNMT RNA (guanine-7-) methyltransferase
RRBP1 ribosome binding protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SRGN serglycin
STC1 stanniocalcin 1
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TREM1 triggering receptor expressed on myeloid cells 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VIM vimentin
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ARMT1 acidic residue methyltransferase 1
ASPN asporin
C2CD5 C2 calcium-dependent domain containing 5
CCNF cyclin F
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
HOXC6 homeobox C6
KRT14 keratin 14, type I
MACF1 microtubule-actin crosslinking factor 1
NFIB nuclear factor I/B
NOP16 NOP16 nucleolar protein
NPY1R neuropeptide Y receptor Y1
PHB prohibitin
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRPF4 pre-mRNA processing factor 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
ZFP36L2 ZFP36 ring finger protein-like 2