BRD-K14027855_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K14027855_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CSRP2 cysteine and glycine-rich protein 2
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGF13 fibroblast growth factor 13
FGFR1 fibroblast growth factor receptor 1
FMOD fibromodulin
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GRB10 growth factor receptor-bound protein 10
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IFI16 interferon, gamma-inducible protein 16
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LBH limb bud and heart development
LOXL2 lysyl oxidase-like 2
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MB myoglobin
MEF2C myocyte enhancer factor 2C
MMP2 matrix metallopeptidase 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEB nebulin
NRN1 neuritin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELO pelota homolog (Drosophila)
PERP PERP, TP53 apoptosis effector
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRR7 proline rich 7 (synaptic)
PTHLH parathyroid hormone-like hormone
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
STC1 stanniocalcin 1
TCF4 transcription factor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TWF1 twinfilin actin binding protein 1
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF395 zinc finger protein 395
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPA aspartoacylase
CALML4 calmodulin-like 4
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSH cathepsin H
DHRS11 dehydrogenase/reductase (SDR family) member 11
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECHDC2 enoyl CoA hydratase domain containing 2
EIF5B eukaryotic translation initiation factor 5B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP1 fatty acid binding protein 1, liver
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KIF20A kinesin family member 20A
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LTBP3 latent transforming growth factor beta binding protein 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
METRN meteorin, glial cell differentiation regulator
MFAP3L microfibrillar-associated protein 3-like
MYO6 myosin VI
NME4 NME/NM23 nucleoside diphosphate kinase 4
OLFM4 olfactomedin 4
PBX2 pre-B-cell leukemia homeobox 2
PCCB propionyl CoA carboxylase, beta polypeptide
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PRKCA protein kinase C, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SRSF11 serine/arginine-rich splicing factor 11
TFF1 trefoil factor 1
TXNDC9 thioredoxin domain containing 9
ZNF318 zinc finger protein 318