BRD-K13810148_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

423 genes differentially expressed following the BRD-K13810148_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAA1 acetyl-CoA acyltransferase 1
ACLY ATP citrate lyase
ACP5 acid phosphatase 5, tartrate resistant
ADA adenosine deaminase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARMCX2 armadillo repeat containing, X-linked 2
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATG2A autophagy related 2A
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C18ORF8 chromosome 18 open reading frame 8
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CALCOCO2 calcium binding and coiled-coil domain 2
CAV2 caveolin 2
CCND3 cyclin D3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHGB chromogranin B
CHI3L2 chitinase 3-like 2
CHMP1B charged multivesicular body protein 1B
CKB creatine kinase, brain
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CREB3L2 cAMP responsive element binding protein 3-like 2
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSV cathepsin V
CYB5R1 cytochrome b5 reductase 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSE dermatan sulfate epimerase
DUSP1 dual specificity phosphatase 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
EZR ezrin
FAM107A family with sequence similarity 107, member A
FAM117A family with sequence similarity 117, member A
FBXO2 F-box protein 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGF9 fibroblast growth factor 9
FGFR4 fibroblast growth factor receptor 4
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
GABARAPL2 GABA(A) receptor-associated protein-like 2
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GM2A GM2 ganglioside activator
GNS glucosamine (N-acetyl)-6-sulfatase
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HPCAL1 hippocalcin-like 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IL32 interleukin 32
INSIG1 insulin induced gene 1
INSR insulin receptor
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KLHL24 kelch-like family member 24
LAMP3 lysosomal-associated membrane protein 3
LDHB lactate dehydrogenase B
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
LPXN leupaxin
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MIR22HG MIR22 host gene
MPP1 membrane protein, palmitoylated 1, 55kDa
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFASC neurofascin
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NPTX2 neuronal pentraxin II
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
OSTM1 osteopetrosis associated transmembrane protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEG10 paternally expressed 10
PIH1D1 PIH1 domain containing 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
PLIN2 perilipin 2
PNMAL1 paraneoplastic Ma antigen family-like 1
POR P450 (cytochrome) oxidoreductase
PRAF2 PRA1 domain family, member 2
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB29 RAB29, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RAE1 ribonucleic acid export 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNF114 ring finger protein 114
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCPEP1 serine carboxypeptidase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SRGN serglycin
ST18 suppression of tumorigenicity 18, zinc finger
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCEAL2 transcription elongation factor A (SII)-like 2
TCTA T-cell leukemia translocation altered
TIGAR TP53 induced glycolysis regulatory phosphatase
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM50B transmembrane protein 50B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSPAN3 tetraspanin 3
TSPAN7 tetraspanin 7
TSPYL2 TSPY-like 2
TTC3 tetratricopeptide repeat domain 3
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WT1 Wilms tumor 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF331 zinc finger protein 331
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ARF6 ADP-ribosylation factor 6
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARMT1 acidic residue methyltransferase 1
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BAG3 BCL2-associated athanogene 3
BARD1 BRCA1 associated RING domain 1
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCND1 cyclin D1
CD34 CD34 molecule
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CKAP4 cytoskeleton-associated protein 4
CTPS2 CTP synthase 2
DCTD dCMP deaminase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEK DEK proto-oncogene
DENND2D DENN/MADD domain containing 2D
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL6 ELOVL fatty acid elongase 6
EMP2 epithelial membrane protein 2
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
ESRP2 epithelial splicing regulatory protein 2
F12 coagulation factor XII (Hageman factor)
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FAM63A family with sequence similarity 63, member A
FHL2 four and a half LIM domains 2
FOXA1 forkhead box A1
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GFRA1 GDNF family receptor alpha 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GTSE1 G-2 and S-phase expressed 1
HDDC2 HD domain containing 2
HDGF hepatoma-derived growth factor
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXC6 homeobox C6
ICT1 immature colon carcinoma transcript 1
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO5 importin 5
IRAK1 interleukin-1 receptor-associated kinase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KIF20A kinesin family member 20A
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LMNB1 lamin B1
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM5 minichromosome maintenance complex component 5
MGMT O-6-methylguanine-DNA methyltransferase
MGST2 microsomal glutathione S-transferase 2
MLPH melanophilin
MPPED2 metallophosphoesterase domain containing 2
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPL23 mitochondrial ribosomal protein L23
MRPS30 mitochondrial ribosomal protein S30
MSMB microseminoprotein, beta-
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC16 mucin 16, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
MZT2A mitotic spindle organizing protein 2A
MZT2B mitotic spindle organizing protein 2B
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPDC1 neural proliferation, differentiation and control, 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBX1 pre-B-cell leukemia homeobox 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRKCH protein kinase C, eta
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
RAB25 RAB25, member RAS oncogene family
RAN RAN, member RAS oncogene family
RCC1 regulator of chromosome condensation 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
RPL38 ribosomal protein L38
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPT9 septin 9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFPQ splicing factor proline/glutamine-rich
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC4 structural maintenance of chromosomes 4
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SPDEF SAM pointed domain containing ETS transcription factor
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STAG2 stromal antigen 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYPL1 synaptophysin-like 1
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM109 transmembrane protein 109
TMPO thymopoietin
TP53 tumor protein p53
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIM22 tripartite motif containing 22
TRIP6 thyroid hormone receptor interactor 6
TSKU tsukushi, small leucine rich proteoglycan
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UCK2 uridine-cytidine kinase 2
UGDH UDP-glucose 6-dehydrogenase
USP3 ubiquitin specific peptidase 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZHX2 zinc fingers and homeoboxes 2
ZWINT ZW10 interacting kinetochore protein