BRD-K13810148_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

395 genes differentially expressed following the BRD-K13810148_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AKTIP AKT interacting protein
ALAS1 5'-aminolevulinate synthase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD46 ankyrin repeat domain 46
ANOS1 anosmin 1
AQP1 aquaporin 1 (Colton blood group)
ARHGAP25 Rho GTPase activating protein 25
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATG2A autophagy related 2A
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL3 B-cell CLL/lymphoma 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
BZW2 basic leucine zipper and W2 domains 2
C14ORF1 chromosome 14 open reading frame 1
C1QB complement component 1, q subcomponent, B chain
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA1 cyclin A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIB1 calcium and integrin binding 1 (calmyrin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
CLU clusterin
CORO1A coronin, actin binding protein, 1A
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CSF1R colony stimulating factor 1 receptor
CSRP1 cysteine and glycine-rich protein 1
CTSW cathepsin W
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
DGKA diacylglycerol kinase, alpha 80kDa
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
DSTN destrin (actin depolymerizing factor)
EAF2 ELL associated factor 2
EFHD1 EF-hand domain family, member D1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F11R F11 receptor
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FBXO2 F-box protein 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP14 FK506 binding protein 14, 22 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
FYB FYN binding protein
G6PD glucose-6-phosphate dehydrogenase
GCA grancalcin, EF-hand calcium binding protein
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA7 golgin A7
GSN gelsolin
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT57 intraflagellar transport 57
IL2RG interleukin 2 receptor, gamma
IL32 interleukin 32
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KIF1A kinesin family member 1A
LBH limb bud and heart development
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRN3 leucine rich repeat neuronal 3
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPT microtubule-associated protein tau
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MDH1 malate dehydrogenase 1, NAD (soluble)
MEF2C myocyte enhancer factor 2C
MGST3 microsomal glutathione S-transferase 3
MICA MHC class I polypeptide-related sequence A
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MPC1 mitochondrial pyruvate carrier 1
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MX1 MX dynamin-like GTPase 1
NAGK N-acetylglucosamine kinase
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NMT2 N-myristoyltransferase 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAT ornithine aminotransferase
OSR2 odd-skipped related transciption factor 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI2 peptidyl arginine deiminase, type II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCYOX1 prenylcysteine oxidase 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLB polymerase (DNA directed), beta
POR P450 (cytochrome) oxidoreductase
PRSS2 protease, serine, 2 (trypsin 2)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
RND1 Rho family GTPase 1
ROGDI rogdi homolog (Drosophila)
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNN stannin
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SST somatostatin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
STX7 syntaxin 7
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SUSD4 sushi domain containing 4
TFRC transferrin receptor
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
VCL vinculin
VWA5A von Willebrand factor A domain containing 5A
WDR47 WD repeat domain 47
WFDC1 WAP four-disulfide core domain 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATF1 activating transcription factor 1
AUTS2 autism susceptibility candidate 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
C7ORF49 chromosome 7 open reading frame 49
CA12 carbonic anhydrase XII
CAPN2 calpain 2, (m/II) large subunit
CARKD carbohydrate kinase domain containing
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CCND2 cyclin D2
CD58 CD58 molecule
CREBBP CREB binding protein
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DCTD dCMP deaminase
DDIT4 DNA-damage-inducible transcript 4
DEK DEK proto-oncogene
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
EREG epiregulin
EXOSC4 exosome component 4
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FBN1 fibrillin 1
FEN1 flap structure-specific endonuclease 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS2 growth arrest-specific 2
GATAD1 GATA zinc finger domain containing 1
GEMIN4 gem (nuclear organelle) associated protein 4
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB7 homeobox B7
IFITM3 interferon induced transmembrane protein 3
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KHNYN KH and NYN domain containing
KIAA0368 KIAA0368
KIF18B kinesin family member 18B
KIZ kizuna centrosomal protein
KLF9 Kruppel-like factor 9
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LCMT2 leucine carboxyl methyltransferase 2
LPL lipoprotein lipase
LRRC41 leucine rich repeat containing 41
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
METTL1 methyltransferase like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
NBN nibrin
NCOA2 nuclear receptor coactivator 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NMI N-myc (and STAT) interactor
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PARVB parvin, beta
PAX2 paired box 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDS5B PDS5 cohesin associated factor B
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRSS23 protease, serine, 23
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB13 RAB13, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REV1 REV1, polymerase (DNA directed)
RNPS1 RNA binding protein S1, serine-rich domain
RPL37A ribosomal protein L37a
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCAND1 SCAN domain containing 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SNRPE small nuclear ribonucleoprotein polypeptide E
SNUPN snurportin 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMPO thymopoietin
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBED1 zinc finger, BED-type containing 1
ZBTB20 zinc finger and BTB domain containing 20
ZC3H4 zinc finger CCCH-type containing 4
ZHX2 zinc fingers and homeoboxes 2
ZIC1 Zic family member 1