BRD-K13662825_dinaciclib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K13662825_dinaciclib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARL3 ADP-ribosylation factor-like 3
BLNK B-cell linker
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BZW2 basic leucine zipper and W2 domains 2
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CD302 CD302 molecule
CD4 CD4 molecule
CD46 CD46 molecule, complement regulatory protein
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTSO cathepsin O
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
DCTD dCMP deaminase
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSE dermatan sulfate epimerase
DST dystonin
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM149A family with sequence similarity 149, member A
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FMO3 flavin containing monooxygenase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXF1 forkhead box F1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HBB hemoglobin, beta
HBD hemoglobin, delta
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
IL7R interleukin 7 receptor
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
NDUFA4 NDUFA4, mitochondrial complex associated
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCBP2 poly(rC) binding protein 2
PDGFC platelet derived growth factor C
PHACTR2 phosphatase and actin regulator 2
PLXNB2 plexin B2
RASA4 RAS p21 protein activator 4
RHOB ras homolog family member B
SCARB2 scavenger receptor class B, member 2
SCP2 sterol carrier protein 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC16A4 solute carrier family 16, member 4
SPP1 secreted phosphoprotein 1
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TBX2 T-box 2
TCTN1 tectonic family member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM47 transmembrane protein 47
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
CALML5 calmodulin-like 5
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
GTPBP8 GTP-binding protein 8 (putative)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXA10 homeobox A10
HOXB7 homeobox B7
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
ITPKB inositol-trisphosphate 3-kinase B
KIAA0101 KIAA0101
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MLPH melanophilin
MRPS2 mitochondrial ribosomal protein S2
MYBPC1 myosin binding protein C, slow type
NES nestin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PLAC8 placenta-specific 8
PMM2 phosphomannomutase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTPRE protein tyrosine phosphatase, receptor type, E
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNM synemin, intermediate filament protein
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
YBX3 Y box binding protein 3