BRD-K13662825_dinaciclib_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-K13662825_dinaciclib_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADD3 adducin 3 (gamma)
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
APOA2 apolipoprotein A-II
AQP3 aquaporin 3 (Gill blood group)
AQP9 aquaporin 9
ASPN asporin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAG1 BCL2-associated athanogene
BAG6 BCL2-associated athanogene 6
BCHE butyrylcholinesterase
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL5 chemokine (C-C motif) ligand 5
CEP70 centrosomal protein 70kDa
CFB complement factor B
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLDN1 claudin 1
CLEC2B C-type lectin domain family 2, member B
COL5A2 collagen, type V, alpha 2
CPM carboxypeptidase M
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
DBN1 drebrin 1
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP1 dual specificity phosphatase 1
DUSP22 dual specificity phosphatase 22
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
F2R coagulation factor II (thrombin) receptor
FADS2 fatty acid desaturase 2
FBLN1 fibulin 1
FLOT1 flotillin 1
FN1 fibronectin 1
FOXF1 forkhead box F1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GLO1 glyoxalase I
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPX1 glutathione peroxidase 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
HCAR3 hydroxycarboxylic acid receptor 3
HEG1 heart development protein with EGF-like domains 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MSN moesin
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NFE2L3 nuclear factor, erythroid 2-like 3
NID2 nidogen 2 (osteonidogen)
NLRP2 NLR family, pyrin domain containing 2
NQO2 NAD(P)H dehydrogenase, quinone 2
NRGN neurogranin (protein kinase C substrate, RC3)
NTS neurotensin
NUCB1 nucleobindin 1
OASL 2'-5'-oligoadenylate synthetase-like
OLFM4 olfactomedin 4
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAT plasminogen activator, tissue
PLS3 plastin 3
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPAP2A phosphatidic acid phosphatase type 2A
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
R3HDM4 R3H domain containing 4
RAB2A RAB2A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RGS4 regulator of G-protein signaling 4
RSAD2 radical S-adenosyl methionine domain containing 2
SCD5 stearoyl-CoA desaturase 5
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT6 septin 6
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC1 stanniocalcin 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TKTL1 transketolase-like 1
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TTC3 tetratricopeptide repeat domain 3
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT4 wingless-type MMTV integration site family, member 4
WSB1 WD repeat and SOCS box containing 1
XAF1 XIAP associated factor 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZMYM2 zinc finger, MYM-type 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADNP activity-dependent neuroprotector homeobox
AIM1 absent in melanoma 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATMIN ATM interactor
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CD164 CD164 molecule, sialomucin
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CREBBP CREB binding protein
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL14 chemokine (C-X-C motif) ligand 14
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELF5 E74-like factor 5 (ets domain transcription factor)
FASTKD5 FAST kinase domains 5
FBP1 fructose-1,6-bisphosphatase 1
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLOD4 glyoxalase domain containing 4
GPSM2 G-protein signaling modulator 2
H2AFX H2A histone family, member X
HEATR1 HEAT repeat containing 1
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MREG melanoregulin
NCOA3 nuclear receptor coactivator 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PANK2 pantothenate kinase 2
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDHX pyruvate dehydrogenase complex, component X
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRNP prion protein
PRSS23 protease, serine, 23
PTRH2 peptidyl-tRNA hydrolase 2
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RNPS1 RNA binding protein S1, serine-rich domain
SCAND1 SCAN domain containing 1
SEC24B SEC24 family member B
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SNX5 sorting nexin 5
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
TACSTD2 tumor-associated calcium signal transducer 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBP TATA box binding protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFB2M transcription factor B2, mitochondrial
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
TMEM97 transmembrane protein 97
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAM1 vascular cell adhesion molecule 1
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF706 zinc finger protein 706