BRD-K13662825_dinaciclib_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K13662825_dinaciclib_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY1 adenylate cyclase 1 (brain)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD36B ankyrin repeat domain 36B
APOA2 apolipoprotein A-II
ASPN asporin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BCHE butyrylcholinesterase
C1ORF54 chromosome 1 open reading frame 54
C6ORF48 chromosome 6 open reading frame 48
CD3D CD3d molecule, delta (CD3-TCR complex)
CD69 CD69 molecule
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSV cathepsin V
DMD dystrophin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP22 dual specificity phosphatase 22
ECM1 extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBE1 hemoglobin, epsilon 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IRX5 iroquois homeobox 5
ISG15 ISG15 ubiquitin-like modifier
ITGA7 integrin, alpha 7
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LGALS3 lectin, galactoside-binding, soluble, 3
LOX lysyl oxidase
LTBP1 latent transforming growth factor beta binding protein 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MPPE1 metallophosphoesterase 1
MSX1 msh homeobox 1
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PDLIM3 PDZ and LIM domain 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POSTN periostin, osteoblast specific factor
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RPL31 ribosomal protein L31
RPS5 ribosomal protein S5
SALL1 spalt-like transcription factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMYD3 SET and MYND domain containing 3
SNX10 sorting nexin 10
SOCS3 suppressor of cytokine signaling 3
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SVIL supervillin
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TNC tenascin C
TNNT1 troponin T type 1 (skeletal, slow)
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUBA1A tubulin, alpha 1a
VWA5A von Willebrand factor A domain containing 5A
WBP5 WW domain binding protein 5
WFDC2 WAP four-disulfide core domain 2
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF274 zinc finger protein 274
ZNF331 zinc finger protein 331
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLCAP bladder cancer associated protein
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLTC clathrin, heavy chain (Hc)
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYD dihydropyrimidine dehydrogenase
EIF5 eukaryotic translation initiation factor 5
ERBB2 erb-b2 receptor tyrosine kinase 2
FBL fibrillarin
FERMT1 fermitin family member 1
FXYD3 FXYD domain containing ion transport regulator 3
GCH1 GTP cyclohydrolase 1
GPX2 glutathione peroxidase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KLF5 Kruppel-like factor 5 (intestinal)
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LASP1 LIM and SH3 protein 1
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MKI67 marker of proliferation Ki-67
MKNK2 MAP kinase interacting serine/threonine kinase 2
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTBP1 polypyrimidine tract binding protein 1
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RNPS1 RNA binding protein S1, serine-rich domain
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SMAD3 SMAD family member 3
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SRSF1 serine/arginine-rich splicing factor 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN2 transgelin 2
TBC1D4 TBC1 domain family, member 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM9SF3 transmembrane 9 superfamily member 3
TP53 tumor protein p53
TPBG trophoblast glycoprotein
TRIM29 tripartite motif containing 29
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBE2I ubiquitin-conjugating enzyme E2I
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XBP1 X-box binding protein 1
XPO7 exportin 7