BRD-K13662825_dinaciclib_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K13662825_dinaciclib_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AQP1 aquaporin 1 (Colton blood group)
C6ORF62 chromosome 6 open reading frame 62
CDV3 CDV3 homolog (mouse)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
FAS Fas cell surface death receptor
FKBP5 FK506 binding protein 5
FRY furry homolog (Drosophila)
G0S2 G0/G1 switch 2
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
HLA-DRA major histocompatibility complex, class II, DR alpha
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL13RA1 interleukin 13 receptor, alpha 1
IL6ST interleukin 6 signal transducer
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA0100 KIAA0100
LOC100286895 cell division cycle 27 homolog pseudogene
LY96 lymphocyte antigen 96
MCL1 myeloid cell leukemia 1
MXI1 MAX interactor 1, dimerization protein
NLRP2 NLR family, pyrin domain containing 2
PDGFD platelet derived growth factor D
PRPF4 pre-mRNA processing factor 4
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCARB2 scavenger receptor class B, member 2
SCD5 stearoyl-CoA desaturase 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TKTL1 transketolase-like 1
TLR4 toll-like receptor 4
TMPRSS3 transmembrane protease, serine 3
TNC tenascin C
TXNL4B thioredoxin-like 4B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
APOD apolipoprotein D
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CCL20 chemokine (C-C motif) ligand 20
CCNB2 cyclin B2
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COCH cochlin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EPHA3 EPH receptor A3
FSTL1 follistatin-like 1
GPM6B glycoprotein M6B
HEATR1 HEAT repeat containing 1
HIST1H4C histone cluster 1, H4c
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
KIAA0101 KIAA0101
LCN2 lipocalin 2
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MELK maternal embryonic leucine zipper kinase
MSMB microseminoprotein, beta-
NOP56 NOP56 ribonucleoprotein
NQO1 NAD(P)H dehydrogenase, quinone 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PPAP2B phosphatidic acid phosphatase type 2B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAE1 ribonucleic acid export 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TXLNA taxilin alpha
VCAN versican