BRD-K13662825_dinaciclib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-K13662825_dinaciclib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD14A abhydrolase domain containing 14A
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANAPC13 anaphase promoting complex subunit 13
AOC3 amine oxidase, copper containing 3
AQP1 aquaporin 1 (Colton blood group)
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
ATXN1 ataxin 1
BAD BCL2-associated agonist of cell death
BEX1 brain expressed, X-linked 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CCL19 chemokine (C-C motif) ligand 19
CD8A CD8a molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKLF chemokine-like factor
CLEC11A C-type lectin domain family 11, member A
CLIC3 chloride intracellular channel 3
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL6A3 collagen, type VI, alpha 3
CPD carboxypeptidase D
CRISP3 cysteine-rich secretory protein 3
CTSD cathepsin D
CXCL10 chemokine (C-X-C motif) ligand 10
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DPY19L1 dpy-19-like 1 (C. elegans)
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FYB FYN binding protein
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HACD1 3-hydroxyacyl-CoA dehydratase 1
HCAR3 hydroxycarboxylic acid receptor 3
HP haptoglobin
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
ISG15 ISG15 ubiquitin-like modifier
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITK IL2-inducible T-cell kinase
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LOX lysyl oxidase
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MEIS1 Meis homeobox 1
METRN meteorin, glial cell differentiation regulator
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MXRA7 matrix-remodelling associated 7
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PLVAP plasmalemma vesicle associated protein
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRDX2 peroxiredoxin 2
PTPRG protein tyrosine phosphatase, receptor type, G
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RHOBTB3 Rho-related BTB domain containing 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARB2 scavenger receptor class B, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH2D1A SH2 domain containing 1A
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
STK10 serine/threonine kinase 10
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TRAC T cell receptor alpha constant
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
TXNL4B thioredoxin-like 4B
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
CACYBP calcyclin binding protein
CCNB2 cyclin B2
CD164 CD164 molecule, sialomucin
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC20 cell division cycle 20
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPF centromere protein F, 350/400kDa
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEK DEK proto-oncogene
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA3 EPH receptor A3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBL fibrillarin
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HEATR1 HEAT repeat containing 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGB2 high mobility group box 2
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IGL immunoglobulin lambda locus
IVNS1ABP influenza virus NS1A binding protein
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF13B kinesin family member 13B
KIF14 kinesin family member 14
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MKNK2 MAP kinase interacting serine/threonine kinase 2
NBPF10 neuroblastoma breakpoint family, member 10
NFIB nuclear factor I/B
NMI N-myc (and STAT) interactor
NOP56 NOP56 ribonucleoprotein
NSFL1C NSFL1 (p97) cofactor (p47)
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PLS1 plastin 1
PNP purine nucleoside phosphorylase
PSD3 pleckstrin and Sec7 domain containing 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAE1 ribonucleic acid export 1
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
SCGB2A2 secretoglobin, family 2A, member 2
SERBP1 SERPINE1 mRNA binding protein 1
SLC38A2 solute carrier family 38, member 2
SLC43A3 solute carrier family 43, member 3
SNX7 sorting nexin 7
STIP1 stress-induced phosphoprotein 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC2 transforming, acidic coiled-coil containing protein 2
TM9SF3 transmembrane 9 superfamily member 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
U2AF1 U2 small nuclear RNA auxiliary factor 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XBP1 X-box binding protein 1