BRD-K13662825_dinaciclib_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K13662825_dinaciclib_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANOS1 anosmin 1
ARHGAP32 Rho GTPase activating protein 32
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
CD8A CD8a molecule
CFD complement factor D (adipsin)
COL1A1 collagen, type I, alpha 1
COLEC12 collectin sub-family member 12
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYBA cytochrome b-245, alpha polypeptide
DHRS2 dehydrogenase/reductase (SDR family) member 2
DICER1 dicer 1, ribonuclease type III
DMTF1 cyclin D binding myb-like transcription factor 1
DSE dermatan sulfate epimerase
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ETV1 ets variant 1
FAM20B family with sequence similarity 20, member B
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FMO2 flavin containing monooxygenase 2 (non-functional)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGKV4-1 immunoglobulin kappa variable 4-1
IL13RA2 interleukin 13 receptor, alpha 2
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LOC100272216 uncharacterized LOC100272216
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METRN meteorin, glial cell differentiation regulator
NEBL nebulette
NGRN neugrin, neurite outgrowth associated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
OLFM1 olfactomedin 1
PRF1 perforin 1 (pore forming protein)
PRR7 proline rich 7 (synaptic)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RHOBTB3 Rho-related BTB domain containing 3
SEPP1 selenoprotein P, plasma, 1
SFTPC surfactant protein C
SIK1 salt-inducible kinase 1
STC1 stanniocalcin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM164 transmembrane protein 164
TRBC1 T cell receptor beta constant 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZNF131 zinc finger protein 131
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ARFIP2 ADP-ribosylation factor interacting protein 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPU centromere protein U
CSRP1 cysteine and glycine-rich protein 1
CTBP2 C-terminal binding protein 2
DCK deoxycytidine kinase
DERA deoxyribose-phosphate aldolase (putative)
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FOXO1 forkhead box O1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
IDI1 isopentenyl-diphosphate delta isomerase 1
JMJD6 jumonji domain containing 6
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LIMS1 LIM and senescent cell antigen-like domains 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NFIB nuclear factor I/B
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
PAPD7 PAP associated domain containing 7
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PEG10 paternally expressed 10
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PPAP2B phosphatidic acid phosphatase type 2B
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RGCC regulator of cell cycle
RNPS1 RNA binding protein S1, serine-rich domain
S100A8 S100 calcium binding protein A8
SLBP stem-loop binding protein
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
ZFP36L1 ZFP36 ring finger protein-like 1