BRD-K13662825_dinaciclib_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K13662825_dinaciclib_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATF3 activating transcription factor 3
C2 complement component 2
CADM1 cell adhesion molecule 1
CES1 carboxylesterase 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL3A1 collagen, type III, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPCAM epithelial cell adhesion molecule
FAM162A family with sequence similarity 162, member A
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FRY furry homolog (Drosophila)
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPSE heparanase
HTRA1 HtrA serine peptidase 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LTBP1 latent transforming growth factor beta binding protein 1
ORM1 orosomucoid 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
REEP5 receptor accessory protein 5
RRAGD Ras-related GTP binding D
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SMYD3 SET and MYND domain containing 3
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TREM1 triggering receptor expressed on myeloid cells 1
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
EIF5A eukaryotic translation initiation factor 5A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
MKNK2 MAP kinase interacting serine/threonine kinase 2
NKX3-1 NK3 homeobox 1
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PRKCA protein kinase C, alpha
PTX3 pentraxin 3, long
RNPS1 RNA binding protein S1, serine-rich domain
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
TACC2 transforming, acidic coiled-coil containing protein 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)