BRD-K13662825_dinaciclib_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K13662825_dinaciclib_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIF1 allograft inflammatory factor 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
BEX4 brain expressed, X-linked 4
CADM1 cell adhesion molecule 1
CAPG capping protein (actin filament), gelsolin-like
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL9A3 collagen, type IX, alpha 3
CTSS cathepsin S
CTSZ cathepsin Z
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EXOSC4 exosome component 4
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLO1 glyoxalase I
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HSPB8 heat shock 22kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLK10 kallikrein-related peptidase 10
LAMP3 lysosomal-associated membrane protein 3
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PERP PERP, TP53 apoptosis effector
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB25 RAB25, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RSAD2 radical S-adenosyl methionine domain containing 2
SCPEP1 serine carboxypeptidase 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLPI secretory leukocyte peptidase inhibitor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TF transferrin
TIMP3 TIMP metallopeptidase inhibitor 3
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WFDC2 WAP four-disulfide core domain 2
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
C1ORF115 chromosome 1 open reading frame 115
CDC20 cell division cycle 20
DKK1 dickkopf WNT signaling pathway inhibitor 1
GLOD4 glyoxalase domain containing 4
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IRS2 insulin receptor substrate 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KRT10 keratin 10, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MLPH melanophilin
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RNPS1 RNA binding protein S1, serine-rich domain
SCGB2A2 secretoglobin, family 2A, member 2
SMAD3 SMAD family member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBAP2 ubiquitin associated protein 2
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
YBX3 Y box binding protein 3