BRD-K13662825_dinaciclib_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

293 genes differentially expressed following the BRD-K13662825_dinaciclib_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD14A abhydrolase domain containing 14A
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA6 annexin A6
AOC3 amine oxidase, copper containing 3
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG2 BCL2-associated athanogene 2
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C9ORF16 chromosome 9 open reading frame 16
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CCND2 cyclin D2
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CFH complement factor H
CFLAR CASP8 and FADD-like apoptosis regulator
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIB1 calcium and integrin binding 1 (calmyrin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLEC11A C-type lectin domain family 11, member A
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COG5 component of oligomeric golgi complex 5
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CPM carboxypeptidase M
CREM cAMP responsive element modulator
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CYBA cytochrome b-245, alpha polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DBN1 drebrin 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELN elastin
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXPH5 exophilin 5
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FGL2 fibrinogen-like 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPM6A glycoprotein M6A
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPX1 glutathione peroxidase 1
GSTA4 glutathione S-transferase alpha 4
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HIP1 huntingtin interacting protein 1
HP haptoglobin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF2 Kruppel-like factor 2
KRT19 keratin 19, type I
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MBP myelin basic protein
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
MFAP4 microfibrillar-associated protein 4
MMP11 matrix metallopeptidase 11
MN1 meningioma (disrupted in balanced translocation) 1
MOXD1 monooxygenase, DBH-like 1
MSRA methionine sulfoxide reductase A
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM1 neural cell adhesion molecule 1
NGRN neugrin, neurite outgrowth associated
NID2 nidogen 2 (osteonidogen)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG3 paternally expressed 3
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
PRR7 proline rich 7 (synaptic)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCG2 secretogranin II
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF21 transcription factor 21
TCF4 transcription factor 4
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM259 transmembrane protein 259
TMSB15A thymosin beta 15a
TPBG trophoblast glycoprotein
TRBC1 T cell receptor beta constant 1
TSPAN5 tetraspanin 5
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TYROBP TYRO protein tyrosine kinase binding protein
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WLS wntless Wnt ligand secretion mediator
WSB1 WD repeat and SOCS box containing 1
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP1 A kinase (PRKA) anchor protein 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C2CD5 C2 calcium-dependent domain containing 5
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CD164 CD164 molecule, sialomucin
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHERP calcium homeostasis endoplasmic reticulum protein
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CTBP2 C-terminal binding protein 2
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FSCN1 fascin actin-bundling protein 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLK5 kallikrein-related peptidase 5
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKSL1 MARCKS-like 1
MELK maternal embryonic leucine zipper kinase
MICU2 mitochondrial calcium uptake 2
MYBPC1 myosin binding protein C, slow type
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PKM pyruvate kinase, muscle
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRPF4 pre-mRNA processing factor 4
PRUNE2 prune homolog 2 (Drosophila)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
RAE1 ribonucleic acid export 1
RAP2A RAP2A, member of RAS oncogene family
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RNPS1 RNA binding protein S1, serine-rich domain
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHB Src homology 2 domain containing adaptor protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SOX9 SRY (sex determining region Y)-box 9
SRSF2 serine/arginine-rich splicing factor 2
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STOML2 stomatin (EPB72)-like 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VGLL4 vestigial-like family member 4
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZDHHC6 zinc finger, DHHC-type containing 6
ZDHHC7 zinc finger, DHHC-type containing 7
ZMYM2 zinc finger, MYM-type 2