BRD-K13646352_PKC-412_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-K13646352_PKC-412_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAMBI BMP and activin membrane-bound inhibitor
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPE centromere protein E, 312kDa
CFB complement factor B
CLIC4 chloride intracellular channel 4
CLU clusterin
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EBI3 Epstein-Barr virus induced 3
EFNA1 ephrin-A1
EHD1 EH-domain containing 1
EPS8 epidermal growth factor receptor pathway substrate 8
FAS Fas cell surface death receptor
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GCH1 GTP cyclohydrolase 1
GLS glutaminase
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HLA-B major histocompatibility complex, class I, B
ICAM1 intercellular adhesion molecule 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL15 interleukin 15
IL32 interleukin 32
IL7R interleukin 7 receptor
ITGAV integrin, alpha V
KIAA0101 KIAA0101
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KYNU kynureninase
LST1 leukocyte specific transcript 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAOB monoamine oxidase B
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
NCK1 NCK adaptor protein 1
NEU1 sialidase 1 (lysosomal sialidase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NKX3-1 NK3 homeobox 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXT2 nuclear transport factor 2-like export factor 2
OPTN optineurin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFC platelet derived growth factor C
PDZK1IP1 PDZK1 interacting protein 1
PLXNB2 plexin B2
PNRC1 proline-rich nuclear receptor coactivator 1
PPA1 pyrophosphatase (inorganic) 1
PPAP2B phosphatidic acid phosphatase type 2B
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGES prostaglandin E synthase
PTX3 pentraxin 3, long
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNF tumor necrosis factor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TRAF1 TNF receptor-associated factor 1
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
AHNAK2 AHNAK nucleoprotein 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOA2 apolipoprotein A-II
AUTS2 autism susceptibility candidate 2
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CCND1 cyclin D1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
COL18A1 collagen, type XVIII, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
ENO1 enolase 1, (alpha)
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ESRP1 epithelial splicing regulatory protein 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
HOXA5 homeobox A5
HOXB7 homeobox B7
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGLL1 immunoglobulin lambda-like polypeptide 1
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
KLK6 kallikrein-related peptidase 6
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PROM1 prominin 1
PRSS3 protease, serine, 3
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
SDC1 syndecan 1
SERINC5 serine incorporator 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SORBS1 sorbin and SH3 domain containing 1
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TRAM2 translocation associated membrane protein 2
TUBA4A tubulin, alpha 4a
TYRP1 tyrosinase-related protein 1
USP9Y ubiquitin specific peptidase 9, Y-linked
UTRN utrophin
VCAN versican
WWTR1 WW domain containing transcription regulator 1