BRD-K13646352_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K13646352_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAA2 acetyl-CoA acyltransferase 2
AURKA aurora kinase A
BZW2 basic leucine zipper and W2 domains 2
C8ORF4 chromosome 8 open reading frame 4
CD83 CD83 molecule
CD9 CD9 molecule
CDK18 cyclin-dependent kinase 18
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EVI2A ecotropic viral integration site 2A
FAM63A family with sequence similarity 63, member A
FN1 fibronectin 1
GPC4 glypican 4
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LPL lipoprotein lipase
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MMD monocyte to macrophage differentiation-associated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS1 regulator of G-protein signaling 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
TESC tescalcin
THBS1 thrombospondin 1
TMEM2 transmembrane protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BCHE butyrylcholinesterase
C7 complement component 7
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CTSH cathepsin H
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FGF9 fibroblast growth factor 9
FGG fibrinogen gamma chain
GLUL glutamate-ammonia ligase
HSPH1 heat shock 105kDa/110kDa protein 1
JUN jun proto-oncogene
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LAMA4 laminin, alpha 4
LAPTM4B lysosomal protein transmembrane 4 beta
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LMO4 LIM domain only 4
LTF lactotransferrin
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
PCDH17 protocadherin 17
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RALGDS ral guanine nucleotide dissociation stimulator
RUFY3 RUN and FYVE domain containing 3
S100A8 S100 calcium binding protein A8
SCEL sciellin
SCG2 secretogranin II
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
TCF4 transcription factor 4
TFRC transferrin receptor
TMSB15A thymosin beta 15a
ZMIZ1 zinc finger, MIZ-type containing 1