BRD-K13646352_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K13646352_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANGPTL4 angiopoietin-like 4
ANXA4 annexin A4
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
CD163 CD163 molecule
CD59 CD59 molecule, complement regulatory protein
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
DARS aspartyl-tRNA synthetase
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ECM1 extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
FN1 fibronectin 1
FRZB frizzled-related protein
FST follistatin
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
ITGB5 integrin, beta 5
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MTSS1 metastasis suppressor 1
NNMT nicotinamide N-methyltransferase
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
OPTN optineurin
OSBPL10 oxysterol binding protein-like 10
PRUNE2 prune homolog 2 (Drosophila)
RAP1GAP RAP1 GTPase activating protein
RET ret proto-oncogene
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SNAI2 snail family zinc finger 2
SPRED2 sprouty-related, EVH1 domain containing 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VCAN versican

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCND1 cyclin D1
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CLDN3 claudin 3
DBF4 DBF4 zinc finger
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
EFHD2 EF-hand domain family, member D2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
GHR growth hormone receptor
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTP1 glutathione S-transferase pi 1
GTSE1 G-2 and S-phase expressed 1
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
HSPH1 heat shock 105kDa/110kDa protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBK PDZ binding kinase
PLK1 polo-like kinase 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS4 regulator of G-protein signaling 4
SOAT1 sterol O-acyltransferase 1
SOX4 SRY (sex determining region Y)-box 4
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
WNT5A wingless-type MMTV integration site family, member 5A