BRD-K13390322_AT-7519_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K13390322_AT-7519_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
CCDC6 coiled-coil domain containing 6
CCL20 chemokine (C-C motif) ligand 20
CD1E CD1e molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP14 dual specificity phosphatase 14
DUSP7 dual specificity phosphatase 7
EDN1 endothelin 1
EFNB2 ephrin-B2
EIF1 eukaryotic translation initiation factor 1
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ENO2 enolase 2 (gamma, neuronal)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS3 fatty acid desaturase 3
FAM107A family with sequence similarity 107, member A
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GORASP2 golgi reassembly stacking protein 2, 55kDa
GPM6B glycoprotein M6B
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IL32 interleukin 32
IL6 interleukin 6
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLHL21 kelch-like family member 21
KRT23 keratin 23, type I
KRT6A keratin 6A, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAX MYC associated factor X
MGLL monoglyceride lipase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MPPED2 metallophosphoesterase domain containing 2
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
NDRG1 N-myc downstream regulated 1
NMU neuromedin U
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTX3 pentraxin 3, long
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RSL1D1 ribosomal L1 domain containing 1
SCG5 secretogranin V
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMAD3 SMAD family member 3
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TGFA transforming growth factor, alpha
TICAM1 toll-like receptor adaptor molecule 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIO trio Rho guanine nucleotide exchange factor
TSC22D3 TSC22 domain family, member 3
UGDH UDP-glucose 6-dehydrogenase
USP6NL USP6 N-terminal like
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ACADVL acyl-CoA dehydrogenase, very long chain
ACOT13 acyl-CoA thioesterase 13
AGR2 anterior gradient 2
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC90B coiled-coil domain containing 90B
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CEP55 centrosomal protein 55kDa
CHMP4A charged multivesicular body protein 4A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKAP4 cytoskeleton-associated protein 4
COL5A2 collagen, type V, alpha 2
COMMD3 COMM domain containing 3
COMMD4 COMM domain containing 4
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DZIP3 DAZ interacting zinc finger protein 3
ETV1 ets variant 1
FABP6 fatty acid binding protein 6, ileal
FAHD2A fumarylacetoacetate hydrolase domain containing 2A
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GALC galactosylceramidase
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GSTA4 glutathione S-transferase alpha 4
GYG1 glycogenin 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDAC6 histone deacetylase 6
HMGB3 high mobility group box 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI35 interferon-induced protein 35
IGHM immunoglobulin heavy constant mu
INTS3 integrator complex subunit 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF20A kinesin family member 20A
KLHDC2 kelch domain containing 2
KYNU kynureninase
LOC100272216 uncharacterized LOC100272216
MDFIC MyoD family inhibitor domain containing
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL12 mitochondrial ribosomal protein L12
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRP1 neuropilin 1
NTS neurotensin
OLFML2B olfactomedin-like 2B
OLFML3 olfactomedin-like 3
PAIP1 poly(A) binding protein interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCM1 pericentriolar material 1
PFN2 profilin 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLBD1 phospholipase B domain containing 1
PNISR PNN-interacting serine/arginine-rich protein
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPIE peptidylprolyl isomerase E (cyclophilin E)
PRKD3 protein kinase D3
PSRC1 proline/serine-rich coiled-coil 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RDX radixin
SEPT10 septin 10
SFRP1 secreted frizzled-related protein 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SMC4 structural maintenance of chromosomes 4
SMYD3 SET and MYND domain containing 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SVIL supervillin
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
THTPA thiamine triphosphatase
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPM2 tropomyosin 2 (beta)
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
WDR13 WD repeat domain 13