BRD-K13390322_AT-7519_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K13390322_AT-7519_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADAMDEC1 ADAM-like, decysin 1
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA1 annexin A1
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
C2CD2 C2 calcium-dependent domain containing 2
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD3D CD3d molecule, delta (CD3-TCR complex)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CES1 carboxylesterase 1
CFI complement factor I
CHN1 chimerin 1
CIB1 calcium and integrin binding 1 (calmyrin)
COLEC12 collectin sub-family member 12
CRTAP cartilage associated protein
CS citrate synthase
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECM1 extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F3 coagulation factor III (thromboplastin, tissue factor)
FGFR3 fibroblast growth factor receptor 3
FMO2 flavin containing monooxygenase 2 (non-functional)
FOXF1 forkhead box F1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
HBE1 hemoglobin, epsilon 1
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-F major histocompatibility complex, class I, F
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
METRN meteorin, glial cell differentiation regulator
MSN moesin
MXRA7 matrix-remodelling associated 7
NDRG1 N-myc downstream regulated 1
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE8B phosphodiesterase 8B
PFKM phosphofructokinase, muscle
PHGDH phosphoglycerate dehydrogenase
PILRB paired immunoglobin-like type 2 receptor beta
PLS3 plastin 3
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGS5 regulator of G-protein signaling 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMYD3 SET and MYND domain containing 3
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TSPAN1 tetraspanin 1
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
UBA7 ubiquitin-like modifier activating enzyme 7
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
VIM vimentin
WLS wntless Wnt ligand secretion mediator
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
ARMCX2 armadillo repeat containing, X-linked 2
ATF5 activating transcription factor 5
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CCND1 cyclin D1
CCNG2 cyclin G2
CD24 CD24 molecule
CENPA centromere protein A
CREBBP CREB binding protein
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DAAM1 dishevelled associated activator of morphogenesis 1
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FGFR2 fibroblast growth factor receptor 2
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
H2AFX H2A histone family, member X
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBB inhibin, beta B
KLHL21 kelch-like family member 21
KRT23 keratin 23, type I
KRT7 keratin 7, type II
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MED13 mediator complex subunit 13
MELK maternal embryonic leucine zipper kinase
MREG melanoregulin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PCM1 pericentriolar material 1
PCNA proliferating cell nuclear antigen
PHF20 PHD finger protein 20
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRRC2C proline-rich coiled-coil 2C
PUM1 pumilio RNA-binding family member 1
QKI QKI, KH domain containing, RNA binding
RAE1 ribonucleic acid export 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SLC38A2 solute carrier family 38, member 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TBL1X transducin (beta)-like 1X-linked
TDG thymine-DNA glycosylase
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WAPAL wings apart-like homolog (Drosophila)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217