BRD-K13390322_AT-7519_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

239 genes differentially expressed following the BRD-K13390322_AT-7519_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BCAP31 B-cell receptor-associated protein 31
BEX1 brain expressed, X-linked 1
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFB complement factor B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKAP4 cytoskeleton-associated protein 4
CKB creatine kinase, brain
CLIC1 chloride intracellular channel 1
CRABP2 cellular retinoic acid binding protein 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLC1 DLC1 Rho GTPase activating protein
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5A eukaryotic translation initiation factor 5A
ENOSF1 enolase superfamily member 1
EXT2 exostosin glycosyltransferase 2
FABP4 fatty acid binding protein 4, adipocyte
FBLN5 fibulin 5
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKBP3 FK506 binding protein 3, 25kDa
FYB FYN binding protein
G6PD glucose-6-phosphate dehydrogenase
GPNMB glycoprotein (transmembrane) nmb
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO4 LIM domain only 4
LUM lumican
MAB21L2 mab-21-like 2 (C. elegans)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK13 mitogen-activated protein kinase 13
MDFIC MyoD family inhibitor domain containing
MMP9 matrix metallopeptidase 9
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NDN necdin, melanoma antigen (MAGE) family member
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NTS neurotensin
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLBD1 phospholipase B domain containing 1
PNMA2 paraneoplastic Ma antigen 2
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRAME preferentially expressed antigen in melanoma
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RPL26L1 ribosomal protein L26-like 1
RSAD2 radical S-adenosyl methionine domain containing 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS4 thrombospondin 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TPGS2 tubulin polyglutamylase complex subunit 2
TPM1 tropomyosin 1 (alpha)
TUSC3 tumor suppressor candidate 3
VAT1 vesicle amine transport 1
VCAN versican

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADNP activity-dependent neuroprotector homeobox
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AIM1 absent in melanoma 1
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAG5 BCL2-associated athanogene 5
BRD1 bromodomain containing 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNF cyclin F
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CHD9 chromodomain helicase DNA binding protein 9
CHERP calcium homeostasis endoplasmic reticulum protein
CHN1 chimerin 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CSNK1D casein kinase 1, delta
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYTH1 cytohesin 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK4 dedicator of cytokinesis 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBXO28 F-box protein 28
FEM1B fem-1 homolog b (C. elegans)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXG1 forkhead box G1
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GEMIN4 gem (nuclear organelle) associated protein 4
HMGA2 high mobility group AT-hook 2
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KCTD12 potassium channel tetramerization domain containing 12
KDM5B lysine (K)-specific demethylase 5B
KIAA0907 KIAA0907
KLK5 kallikrein-related peptidase 5
KYNU kynureninase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
METTL18 methyltransferase like 18
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDE4D phosphodiesterase 4D, cAMP-specific
PER2 period circadian clock 2
PFKP phosphofructokinase, platelet
PHIP pleckstrin homology domain interacting protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POGK pogo transposable element with KRAB domain
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RBM15 RNA binding motif protein 15
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF219 ring finger protein 219
RNF38 ring finger protein 38
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSBN1 round spermatid basic protein 1
RYBP RING1 and YY1 binding protein
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SNX11 sorting nexin 11
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
STK26 serine/threonine protein kinase 26
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBP TATA box binding protein
TBPL1 TBP-like 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
U2SURP U2 snRNP-associated SURP domain containing
USP1 ubiquitin specific peptidase 1
USP6NL USP6 N-terminal like
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF22 zinc finger protein 22