BRD-K13390322_AT-7519_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

254 genes differentially expressed following the BRD-K13390322_AT-7519_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMT aminomethyltransferase
ANXA4 annexin A4
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BACE2 beta-site APP-cleaving enzyme 2
BCAP31 B-cell receptor-associated protein 31
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BMP4 bone morphogenetic protein 4
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CETN2 centrin, EF-hand protein, 2
CETN3 centrin, EF-hand protein, 3
CFB complement factor B
CFH complement factor H
CHN2 chimerin 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
COMP cartilage oligomeric matrix protein
CTSH cathepsin H
CXADR coxsackie virus and adenovirus receptor
CYB5B cytochrome b5 type B (outer mitochondrial membrane)
DCN decorin
DYNLT3 dynein, light chain, Tctex-type 3
EFHD1 EF-hand domain family, member D1
EXPH5 exophilin 5
FLT1 fms-related tyrosine kinase 1
GJA1 gap junction protein, alpha 1, 43kDa
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6A glycoprotein M6A
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ISYNA1 inositol-3-phosphate synthase 1
KRT18 keratin 18, type I
LAMB2 laminin, beta 2 (laminin S)
LOXL1 lysyl oxidase-like 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP7 matrix metallopeptidase 7
NMU neuromedin U
NNT nicotinamide nucleotide transhydrogenase
NPR3 natriuretic peptide receptor 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRP1 neuropilin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCOLCE procollagen C-endopeptidase enhancer
PECAM1 platelet/endothelial cell adhesion molecule 1
PLBD1 phospholipase B domain containing 1
PLXND1 plexin D1
PODXL podocalyxin-like
PRPS2 phosphoribosyl pyrophosphate synthetase 2
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RAD51C RAD51 paralog C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMYD3 SET and MYND domain containing 3
SORT1 sortilin 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SST somatostatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
THBS2 thrombospondin 2
TMEM123 transmembrane protein 123
TMEM230 transmembrane protein 230
TMEM47 transmembrane protein 47
TPM2 tropomyosin 2 (beta)
VWF von Willebrand factor

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
ANGPTL4 angiopoietin-like 4
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
AURKA aurora kinase A
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK17 cyclin-dependent kinase 17
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHIC2 cysteine-rich hydrophobic domain 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CSNK1D casein kinase 1, delta
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FEM1B fem-1 homolog b (C. elegans)
FEM1C fem-1 homolog c (C. elegans)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRMD4B FERM domain containing 4B
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GGNBP2 gametogenetin binding protein 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
IL32 interleukin 32
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
ITPKC inositol-trisphosphate 3-kinase C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KIAA0907 KIAA0907
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MCTP1 multiple C2 domains, transmembrane 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL2 pleiomorphic adenoma gene-like 2
POGK pogo transposable element with KRAB domain
PPIF peptidylprolyl isomerase F
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PTHLH parathyroid hormone-like hormone
PTX3 pentraxin 3, long
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RND1 Rho family GTPase 1
RNMT RNA (guanine-7-) methyltransferase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RYBP RING1 and YY1 binding protein
S100B S100 calcium binding protein B
SCAF8 SR-related CTD-associated factor 8
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TEX10 testis expressed 10
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TRAF4 TNF receptor-associated factor 4
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2