BRD-K13390322_AT-7519_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K13390322_AT-7519_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT13 acyl-CoA thioesterase 13
AGRN agrin
ANOS1 anosmin 1
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BHLHE40 basic helix-loop-helix family, member e40
CD24 CD24 molecule
CES1 carboxylesterase 1
CFI complement factor I
CLGN calmegin
CTGF connective tissue growth factor
CTSG cathepsin G
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R1 cytochrome b5 reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNALI1 dynein, axonemal, light intermediate chain 1
EFNB2 ephrin-B2
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
ESR1 estrogen receptor 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPC3 glypican 3
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KLF10 Kruppel-like factor 10
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
MECOM MDS1 and EVI1 complex locus
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPPED2 metallophosphoesterase domain containing 2
MSLN mesothelin
MX1 MX dynamin-like GTPase 1
NME5 NME/NM23 family member 5
OASL 2'-5'-oligoadenylate synthetase-like
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCDH17 protocadherin 17
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PODXL podocalyxin-like
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SST somatostatin
TARBP1 TAR (HIV-1) RNA binding protein 1
TCTN1 tectonic family member 1
TFPI2 tissue factor pathway inhibitor 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TPPP3 tubulin polymerization-promoting protein family member 3

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ARID5B AT rich interactive domain 5B (MRF1-like)
AURKB aurora kinase B
AXIN1 axin 1
CALHM2 calcium homeostasis modulator 2
CBR3 carbonyl reductase 3
CCNF cyclin F
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
FHL1 four and a half LIM domains 1
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GPR137B G protein-coupled receptor 137B
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IRF4 interferon regulatory factor 4
ISG20 interferon stimulated exonuclease gene 20kDa
JADE2 jade family PHD finger 2
KLF4 Kruppel-like factor 4 (gut)
KLHL9 kelch-like family member 9
KYNU kynureninase
LXN latexin
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
NOTCH1 notch 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZRN3 PDZ domain containing ring finger 3
PLXNC1 plexin C1
PMP22 peripheral myelin protein 22
PNISR PNN-interacting serine/arginine-rich protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SKAP2 src kinase associated phosphoprotein 2
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TSC22D3 TSC22 domain family, member 3