BRD-K13390322_AT-7519_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-K13390322_AT-7519_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ACKR3 atypical chemokine receptor 3
AHNAK2 AHNAK nucleoprotein 2
AIF1 allograft inflammatory factor 1
AMD1 adenosylmethionine decarboxylase 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANO1 anoctamin 1, calcium activated chloride channel
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APC adenomatous polyposis coli
APLP1 amyloid beta (A4) precursor-like protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOC2 apolipoprotein C-II
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BAG3 BCL2-associated athanogene 3
BAG4 BCL2-associated athanogene 4
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CCNA1 cyclin A1
CD52 CD52 molecule
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA4 defensin, alpha 4, corticostatin
DPT dermatopontin
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
ECM1 extracellular matrix protein 1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR3 early growth response 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FEM1C fem-1 homolog c (C. elegans)
FMO2 flavin containing monooxygenase 2 (non-functional)
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FRS2 fibroblast growth factor receptor substrate 2
FRZB frizzled-related protein
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GOLGA4 golgin A4
GPNMB glycoprotein (transmembrane) nmb
GSTT1 glutathione S-transferase theta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IL1RAP interleukin 1 receptor accessory protein
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMO1 methylsterol monooxygenase 1
MSX1 msh homeobox 1
MXRA7 matrix-remodelling associated 7
NDRG1 N-myc downstream regulated 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG3 paternally expressed 3
PER2 period circadian clock 2
PI3 peptidase inhibitor 3, skin-derived
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLAGL1 pleiomorphic adenoma gene-like 1
PRDM2 PR domain containing 2, with ZNF domain
PRNP prion protein
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PTPRO protein tyrosine phosphatase, receptor type, O
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB2A RAB2A, member RAS oncogene family
REEP5 receptor accessory protein 5
REG1A regenerating islet-derived 1 alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RPL37A ribosomal protein L37a
RPS21 ribosomal protein S21
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCG5 secretogranin V
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SQLE squalene epoxidase
SRSF6 serine/arginine-rich splicing factor 6
TACSTD2 tumor-associated calcium signal transducer 2
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TGM4 transglutaminase 4
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TPD52 tumor protein D52
TRA2A transformer 2 alpha homolog (Drosophila)
TRIM36 tripartite motif containing 36
TRIO trio Rho guanine nucleotide exchange factor
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB10 zinc finger and BTB domain containing 10
ZBTB43 zinc finger and BTB domain containing 43
ZMYM2 zinc finger, MYM-type 2
ZNF136 zinc finger protein 136
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C3ORF14 chromosome 3 open reading frame 14
C4ORF27 chromosome 4 open reading frame 27
CADPS2 Ca++-dependent secretion activator 2
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
DCN decorin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECT2 epithelial cell transforming 2
ETV1 ets variant 1
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAT2B methionine adenosyltransferase II, beta
MBNL1 muscleblind-like splicing regulator 1
MRPL12 mitochondrial ribosomal protein L12
MSH2 mutS homolog 2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NEK7 NIMA-related kinase 7
NMI N-myc (and STAT) interactor
NR2F2 nuclear receptor subfamily 2, group F, member 2
OIP5 Opa interacting protein 5
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFC platelet derived growth factor C
PDS5A PDS5 cohesin associated factor A
PLA2G16 phospholipase A2, group XVI
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCA protein kinase C, alpha
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RACGAP1 Rac GTPase activating protein 1
RHOBTB3 Rho-related BTB domain containing 3
RPAP3 RNA polymerase II associated protein 3
RRM2 ribonucleotide reductase M2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
SPDL1 spindle apparatus coiled-coil protein 1
TBC1D4 TBC1 domain family, member 4
TCF12 transcription factor 12
THYN1 thymocyte nuclear protein 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAK2 trafficking protein, kinesin binding 2
TSPYL5 TSPY-like 5
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)