BRD-K13390322_AT-7519_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

271 genes differentially expressed following the BRD-K13390322_AT-7519_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADORA2B adenosine A2b receptor
AIF1 allograft inflammatory factor 1
AKAP8 A kinase (PRKA) anchor protein 8
ANKRD11 ankyrin repeat domain 11
APLP1 amyloid beta (A4) precursor-like protein 1
AQP8 aquaporin 8
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
BMP2 bone morphogenetic protein 2
C1ORF106 chromosome 1 open reading frame 106
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA11 carbonic anhydrase XI
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCDC68 coiled-coil domain containing 68
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCND2 cyclin D2
CD14 CD14 molecule
CD163 CD163 molecule
CD177 CD177 molecule
CDC25A cell division cycle 25A
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CELF2 CUGBP, Elav-like family member 2
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CST3 cystatin C
CSTA cystatin A (stefin A)
CTSG cathepsin G
CTSK cathepsin K
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA4 defensin, alpha 4, corticostatin
DLK1 delta-like 1 homolog (Drosophila)
DPT dermatopontin
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNB2 ephrin-B2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETHE1 ethylmalonic encephalopathy 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FJX1 four jointed box 1 (Drosophila)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GLUL glutamate-ammonia ligase
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GSTT1 glutathione S-transferase theta 1
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLF hepatic leukemia factor
HOXD1 homeobox D1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGHMBP2 immunoglobulin mu binding protein 2
IL7R interleukin 7 receptor
IRF6 interferon regulatory factor 6
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LOC100507397 uncharacterized LOC100507397
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1E metallothionein 1E
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
NAP1L2 nucleosome assembly protein 1-like 2
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NXF3 nuclear RNA export factor 3
PEG3 paternally expressed 3
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLTP phospholipid transfer protein
PMP22 peripheral myelin protein 22
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PRRC2C proline-rich coiled-coil 2C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RCAN2 regulator of calcineurin 2
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNF24 ring finger protein 24
RNMT RNA (guanine-7-) methyltransferase
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFN stratifin
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SST somatostatin
STYK1 serine/threonine/tyrosine kinase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX thymocyte selection-associated high mobility group box
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TYROBP TYRO protein tyrosine kinase binding protein
USP36 ubiquitin specific peptidase 36
VWA5A von Willebrand factor A domain containing 5A
ZBTB10 zinc finger and BTB domain containing 10
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASCC3 activating signal cointegrator 1 complex subunit 3
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AURKB aurora kinase B
BRCA1 breast cancer 1, early onset
BTG1 B-cell translocation gene 1, anti-proliferative
C4ORF27 chromosome 4 open reading frame 27
C6ORF62 chromosome 6 open reading frame 62
C9ORF3 chromosome 9 open reading frame 3
CAST calpastatin
CCDC53 coiled-coil domain containing 53
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25B cell division cycle 25B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLCN3 chloride channel, voltage-sensitive 3
CLIC3 chloride intracellular channel 3
CNN1 calponin 1, basic, smooth muscle
COA3 cytochrome c oxidase assembly factor 3
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COMMD3 COMM domain containing 3
COMMD4 COMM domain containing 4
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FADS1 fatty acid desaturase 1
FKBP11 FK506 binding protein 11, 19 kDa
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
GPSM2 G-protein signaling modulator 2
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
HDDC2 HD domain containing 2
HOXA5 homeobox A5
HOXC6 homeobox C6
ICAM2 intercellular adhesion molecule 2
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
MAB21L2 mab-21-like 2 (C. elegans)
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MBNL1 muscleblind-like splicing regulator 1
MEGF9 multiple EGF-like-domains 9
MET MET proto-oncogene, receptor tyrosine kinase
MRPL12 mitochondrial ribosomal protein L12
MSRB1 methionine sulfoxide reductase B1
NEK7 NIMA-related kinase 7
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OSBPL8 oxysterol binding protein-like 8
PAWR PRKC, apoptosis, WT1, regulator
PCM1 pericentriolar material 1
PDLIM5 PDZ and LIM domain 5
PKP4 plakophilin 4
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGES prostaglandin E synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBPMS RNA binding protein with multiple splicing
REXO2 RNA exonuclease 2
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SFRP1 secreted frizzled-related protein 1
SH3BP4 SH3-domain binding protein 4
SLC16A6 solute carrier family 16, member 6
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SMC4 structural maintenance of chromosomes 4
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPTSSA serine palmitoyltransferase, small subunit A
STMN1 stathmin 1
TBL1X transducin (beta)-like 1X-linked
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMSB15A thymosin beta 15a
TNS1 tensin 1
TPM1 tropomyosin 1 (alpha)
TRAK2 trafficking protein, kinesin binding 2
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UXT ubiquitously-expressed, prefoldin-like chaperone
VCAN versican
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)