BRD-K13094524_PFI-1_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K13094524_PFI-1_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
AKIRIN1 akirin 1
ATF3 activating transcription factor 3
C6ORF62 chromosome 6 open reading frame 62
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIRBP cold inducible RNA binding protein
CYBA cytochrome b-245, alpha polypeptide
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFNB2 ephrin-B2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRN granulin
GSTZ1 glutathione S-transferase zeta 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
KLF4 Kruppel-like factor 4 (gut)
MAMLD1 mastermind-like domain containing 1
MMP1 matrix metallopeptidase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAT ornithine aminotransferase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PROM1 prominin 1
PTN pleiotrophin
RGS2 regulator of G-protein signaling 2
SDC2 syndecan 2
SIK1 salt-inducible kinase 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SMC1A structural maintenance of chromosomes 1A
STK26 serine/threonine protein kinase 26
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
UBE2S ubiquitin-conjugating enzyme E2S
VCL vinculin

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABLIM1 actin binding LIM protein 1
AEBP1 AE binding protein 1
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP1 aquaporin 1 (Colton blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
CA12 carbonic anhydrase XII
CCDC109B coiled-coil domain containing 109B
CD163 CD163 molecule
CFI complement factor I
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
DPYSL3 dihydropyrimidinase-like 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAS Fas cell surface death receptor
FBLN1 fibulin 1
GIMAP6 GTPase, IMAP family member 6
GPATCH8 G patch domain containing 8
HOPX HOP homeobox
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
JADE2 jade family PHD finger 2
KRT18 keratin 18, type I
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPK13 mitogen-activated protein kinase 13
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MPZL2 myelin protein zero-like 2
MXRA5 matrix-remodelling associated 5
PBX1 pre-B-cell leukemia homeobox 1
PDGFD platelet derived growth factor D
POSTN periostin, osteoblast specific factor
PRKCH protein kinase C, eta
PTGIS prostaglandin I2 (prostacyclin) synthase
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS5 regulator of G-protein signaling 5
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM204 transmembrane protein 204
ZFPM2 zinc finger protein, FOG family member 2