BRD-K13094524_PFI-1_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K13094524_PFI-1_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
BPHL biphenyl hydrolase-like (serine hydrolase)
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CIRBP cold inducible RNA binding protein
CLGN calmegin
CTSD cathepsin D
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DSP desmoplakin
EFNA1 ephrin-A1
GPX1 glutathione peroxidase 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFI27 interferon, alpha-inducible protein 27
MBNL2 muscleblind-like splicing regulator 2
MYO6 myosin VI
NQO1 NAD(P)H dehydrogenase, quinone 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDZD2 PDZ domain containing 2
PNMA1 paraneoplastic Ma antigen 1
PODXL podocalyxin-like
PRAF2 PRA1 domain family, member 2
PRKCQ protein kinase C, theta
RGS4 regulator of G-protein signaling 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
TUBB2A tubulin, beta 2A class IIa
U2AF1 U2 small nuclear RNA auxiliary factor 1
ZC2HC1A zinc finger, C2HC-type containing 1A

decreased expression

Symbol Name
AGR2 anterior gradient 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC86 coiled-coil domain containing 86
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL4A2 collagen, type IV, alpha 2
COMP cartilage oligomeric matrix protein
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYB5R2 cytochrome b5 reductase 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DIXDC1 DIX domain containing 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
ELF5 E74-like factor 5 (ets domain transcription factor)
F3 coagulation factor III (thromboplastin, tissue factor)
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HCAR3 hydroxycarboxylic acid receptor 3
HK2 hexokinase 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KDSR 3-ketodihydrosphingosine reductase
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRT17 keratin 17, type I
LMNB1 lamin B1
LTF lactotransferrin
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
METTL21B methyltransferase like 21B
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MTA1 metastasis associated 1
MYH11 myosin, heavy chain 11, smooth muscle
NLGN4X neuroligin 4, X-linked
PDE4B phosphodiesterase 4B, cAMP-specific
PKP1 plakophilin 1
PLK1 polo-like kinase 1
PLN phospholamban
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCH protein kinase C, eta
PTK2 protein tyrosine kinase 2
PYCR1 pyrroline-5-carboxylate reductase 1
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BP4 SH3-domain binding protein 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK26 serine/threonine protein kinase 26
TCF3 transcription factor 3
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGIF1 TGFB-induced factor homeobox 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon