BRD-K12867552_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

287 genes differentially expressed following the BRD-K12867552_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ACSF2 acyl-CoA synthetase family member 2
ADCY9 adenylate cyclase 9
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
ARHGAP29 Rho GTPase activating protein 29
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
ASRGL1 asparaginase like 1
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BAD BCL2-associated agonist of cell death
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALCOCO2 calcium binding and coiled-coil domain 2
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNG2 cyclin G2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGRRF1 cell growth regulator with ring finger domain 1
CHKA choline kinase alpha
COL10A1 collagen, type X, alpha 1
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CREM cAMP responsive element modulator
CRIP1 cysteine-rich protein 1 (intestinal)
CRLF1 cytokine receptor-like factor 1
CTGF connective tissue growth factor
CTSV cathepsin V
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL2 dihydropyrimidinase-like 2
DSTN destrin (actin depolymerizing factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FBLN5 fibulin 5
FBXO2 F-box protein 2
FN1 fibronectin 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GREM1 gremlin 1, DAN family BMP antagonist
GRK5 G protein-coupled receptor kinase 5
GSTM3 glutathione S-transferase mu 3 (brain)
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT20 intraflagellar transport 20
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KCTD5 potassium channel tetramerization domain containing 5
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1A microtubule-associated protein 1A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
METRN meteorin, glial cell differentiation regulator
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MPC1 mitochondrial pyruvate carrier 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA7 matrix-remodelling associated 7
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEU1 sialidase 1 (lysosomal sialidase)
NLRP2 NLR family, pyrin domain containing 2
NPC2 Niemann-Pick disease, type C2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OAT ornithine aminotransferase
OPN3 opsin 3
OSBPL1A oxysterol binding protein-like 1A
OSR2 odd-skipped related transciption factor 2
OSTM1 osteopetrosis associated transmembrane protein 1
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PMP22 peripheral myelin protein 22
PRDX1 peroxiredoxin 1
PSPH phosphoserine phosphatase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB29 RAB29, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
ROGDI rogdi homolog (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNAP23 synaptosomal-associated protein, 23kDa
SNN stannin
SPAG9 sperm associated antigen 9
SRGN serglycin
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
SUGCT succinyl-CoA:glutarate-CoA transferase
TBPL1 TBP-like 1
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UBE2A ubiquitin-conjugating enzyme E2A
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP7 vesicle-associated membrane protein 7
VAT1 vesicle amine transport 1
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
AIM2 absent in melanoma 2
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP9 aquaporin 9
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF5 activating transcription factor 5
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CCBL2 cysteine conjugate-beta lyase 2
CCNA2 cyclin A2
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CKAP4 cytoskeleton-associated protein 4
CSK c-src tyrosine kinase
CTBP1 C-terminal binding protein 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF4B eukaryotic translation initiation factor 4B
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERBB2 erb-b2 receptor tyrosine kinase 2
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FANCL Fanconi anemia, complementation group L
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATAD1 GATA zinc finger domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GOSR1 golgi SNAP receptor complex member 1
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GTPBP8 GTP-binding protein 8 (putative)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB2 homeobox B2
IFI16 interferon, gamma-inducible protein 16
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBP lipopolysaccharide binding protein
LTF lactotransferrin
LYZ lysozyme
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MPZL2 myelin protein zero-like 2
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PGLS 6-phosphogluconolactonase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPS11 ribosomal protein S11
RTP4 receptor (chemosensory) transporter protein 4
S100A8 S100 calcium binding protein A8
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SNRPE small nuclear ribonucleoprotein polypeptide E
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCERG1 transcription elongation regulator 1
TDO2 tryptophan 2,3-dioxygenase
TGOLN2 trans-golgi network protein 2
TP53 tumor protein p53
TPBG trophoblast glycoprotein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
ZBTB20 zinc finger and BTB domain containing 20
ZNF512B zinc finger protein 512B
ZNF652 zinc finger protein 652