BRD-K12867552_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

221 genes differentially expressed following the BRD-K12867552_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAD8 acyl-CoA dehydrogenase family, member 8
ACOT7 acyl-CoA thioesterase 7
ADAM10 ADAM metallopeptidase domain 10
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATG2A autophagy related 2A
BACE2 beta-site APP-cleaving enzyme 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC92 coiled-coil domain containing 92
CCND3 cyclin D3
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COG5 component of oligomeric golgi complex 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CPB1 carboxypeptidase B1 (tissue)
CSRP1 cysteine and glycine-rich protein 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R1 cytochrome b5 reductase 1
CYTH1 cytohesin 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
ENDOD1 endonuclease domain containing 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FZD2 frizzled class receptor 2
GCA grancalcin, EF-hand calcium binding protein
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
GSN gelsolin
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HIST1H1C histone cluster 1, H1c
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
KCTD5 potassium channel tetramerization domain containing 5
LACTB2 lactamase, beta 2
LDHB lactate dehydrogenase B
LEPROTL1 leptin receptor overlapping transcript-like 1
LGMN legumain
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAGEB2 melanoma antigen family B2
MT1X metallothionein 1X
NEFH neurofilament, heavy polypeptide
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
PPARD peroxisome proliferator-activated receptor delta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRE protein tyrosine phosphatase, receptor type, E
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS4 regulator of G-protein signaling 4
RIOK3 RIO kinase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN3 reticulon 3
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMYD3 SET and MYND domain containing 3
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP1 syntaxin binding protein 1
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBPL1 TBP-like 1
TBX3 T-box 3
TEX2 testis expressed 2
TFF3 trefoil factor 3 (intestinal)
TKTL1 transketolase-like 1
TLE4 transducin-like enhancer of split 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAK2 trafficking protein, kinesin binding 2
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UBE2A ubiquitin-conjugating enzyme E2A
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR47 WD repeat domain 47
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOA1 apolipoprotein A-I
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
AUTS2 autism susceptibility candidate 2
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CD24 CD24 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CLIC4 chloride intracellular channel 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
FAM198B family with sequence similarity 198, member B
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS2 growth arrest-specific 2
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GSTT1 glutathione S-transferase theta 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HDDC2 HD domain containing 2
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
ITGA6 integrin, alpha 6
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
LAMB1 laminin, beta 1
LPP LIM domain containing preferred translocation partner in lipoma
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PAX6 paired box 6
PDAP1 PDGFA associated protein 1
PGC progastricsin (pepsinogen C)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PLN phospholamban
POU2AF1 POU class 2 associating factor 1
PRMT1 protein arginine methyltransferase 1
PTMA prothymosin, alpha
PTPRO protein tyrosine phosphatase, receptor type, O
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD23B RAD23 homolog B (S. cerevisiae)
RBM26 RNA binding motif protein 26
RBP4 retinol binding protein 4, plasma
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SENP6 SUMO1/sentrin specific peptidase 6
SEPP1 selenoprotein P, plasma, 1
SET SET nuclear proto-oncogene
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS4 thrombospondin 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TSKU tsukushi, small leucine rich proteoglycan
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
VIL1 villin 1
YBX3 Y box binding protein 3
ZBTB38 zinc finger and BTB domain containing 38
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91